{"id":"W2080417833","doi":"10.1158/1535-7163.targ-11-c210","title":"Abstract C210: Microregional distribution and activity of camptothecins in tumor xenografts.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Spinal Cord Injury BC","funders":"","keywords":"Topotecan; Irinotecan; Camptothecin; Distribution (mathematics); Pharmacology; Topoisomerase; Medicine; Cancer research; Cancer; Chemistry; Pathology; Chemotherapy; Internal medicine; Enzyme; Biochemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001448023,0.0001424219,0.0002799332,0.00007490983,0.0000300346,0.000004348402,0.00007571017,0.0000598883,0.00004879947],"category_scores_gemma":[0.000008981673,0.0001228555,0.00006834042,0.00017765,0.0002510279,0.00003777867,0.00003900004,0.0002270761,9.090297e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001088647,"about_ca_system_score_gemma":0.0001211796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009206991,"about_ca_topic_score_gemma":0.0002192357,"domain_scores_codex":[0.9991102,0.00003613849,0.0001680547,0.0002044479,0.0002300938,0.0002510988],"domain_scores_gemma":[0.9995463,0.00002498135,0.00007927146,0.0002026073,0.00008202228,0.00006475125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001210248,0.0003978646,0.02840987,0.000130409,0.0003276546,0.00009150487,0.0010057,0.000002200578,0.9512603,0.0001255181,0.00001810151,0.01702061],"study_design_scores_gemma":[0.0013391,0.0001896118,0.5773979,0.0001115351,0.00004674864,0.00001649133,0.00005939999,0.00008082168,0.4193644,0.0002594568,0.001014571,0.000119994],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960983,0.002418509,0.0003678088,0.0003565445,0.00004490545,0.0003276233,0.00008784855,0.00001609059,0.0002823198],"genre_scores_gemma":[0.998364,0.001118125,0.00008594171,0.0003265674,0.00001887001,0.0000372957,0.00001084927,0.00001989947,0.00001842334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.548988,"threshold_uncertainty_score":0.5009901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04322675754856139,"score_gpt":0.3225822618707858,"score_spread":0.2793555043222244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}