{"id":"W2080417833","doi":"10.1158/1535-7163.targ-11-c210","title":"Abstract C210: Microregional distribution and activity of camptothecins in tumor xenografts.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Spinal Cord Injury BC","funders":"","keywords":"Topotecan; Irinotecan; Camptothecin; Distribution (mathematics); Pharmacology; Topoisomerase; Medicine; Cancer research; Cancer; Chemistry; Pathology; Chemotherapy; Internal medicine; Enzyme; Biochemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009177851,0.0002294457,0.0001288317,0.0002485699,0.0001275413,0.0001659377,0.0001326744,0.0002257745,0.00244941],"category_scores_gemma":[0.00007147345,0.000120722,0.0001335461,0.0001797775,0.0001688442,0.0001598029,0.0001029674,0.0004961215,0.0004476656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004279752,"about_ca_system_score_gemma":0.0002030995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003343851,"about_ca_topic_score_gemma":0.002812237,"domain_scores_codex":[0.9999274,0.000004326424,0.000003343294,0.0000238294,0.00002203998,0.00001899323],"domain_scores_gemma":[0.9999158,0.0000221218,0.00002223278,0.000007950714,0.0000130032,0.00001875678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004799291,0.000009452393,0.00009464601,0.00001016654,9.326632e-7,0.0000215176,0.000007325541,0.00002770846,0.9992925,0.0000175801,0.00003174174,0.0004384023],"study_design_scores_gemma":[0.000006659625,0.0003770626,0.01243745,0.000003929475,0.000006743951,0.0002353481,0.00002981331,0.0007104959,0.9848567,0.00001531244,0.00131705,0.000003469112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894916,0.001603553,0.003499219,0.00009387992,0.00003242677,0.00004932229,0.001413713,0.0001447666,0.003671524],"genre_scores_gemma":[0.9834397,0.0008109618,0.004886846,0.00003721753,0.00001330928,0.00007616867,0.001833018,0.00004966572,0.008852957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003343851,"threshold_uncertainty_score":0.008194149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04322675754856139,"score_gpt":0.3225822618707858,"score_spread":0.2793555043222244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}