{"id":"W2080430705","doi":"10.1158/1535-7163.targ-11-b24","title":"Abstract B24: Detection of O6- and N7-methylguanine adducts by LC/MS in brain tumor tissues obtained from patients treated with temozolomide.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Université de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Temozolomide; O-6-methylguanine-DNA methyltransferase; Cancer; Medicine; Guanine; Cancer research; Regimen; Adduct; Radiation therapy; Methylation; DNA; Glioblastoma; Oncology; Chemistry; Internal medicine; Methyltransferase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133851,0.0002193662,0.0002824015,0.00007691457,0.00005269823,0.00000896593,0.0001152482,0.0001878385,0.0004224915],"category_scores_gemma":[0.00001787728,0.0001876704,0.00004034228,0.0002034184,0.0001609973,0.00007605057,0.00002803771,0.0003661941,0.000004378543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007771242,"about_ca_system_score_gemma":0.00003471135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001665785,"about_ca_topic_score_gemma":0.0002763493,"domain_scores_codex":[0.9989172,0.0001149614,0.0002925151,0.0002950226,0.0001227444,0.0002575371],"domain_scores_gemma":[0.9993649,0.0001158042,0.0001676952,0.0001565233,0.00009699045,0.00009809567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007966355,0.0004037856,0.04742293,0.00002273239,0.0002605617,0.00001803087,0.0005120698,0.000008252376,0.9154021,0.000009424783,0.00006300105,0.03508045],"study_design_scores_gemma":[0.002266657,0.0002805137,0.04417406,0.00002862046,0.0001537081,0.000001526108,0.00006180914,0.0001725161,0.9367565,0.0001311309,0.01575602,0.0002169641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959872,0.002692097,0.00007649689,0.0001355573,0.00009637942,0.000326555,0.0001531478,0.00003327242,0.0004992669],"genre_scores_gemma":[0.9981765,0.0004772221,0.0001217846,0.001008053,0.00002439004,0.00004526705,0.00005039842,0.00003336947,0.00006297923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03486349,"threshold_uncertainty_score":0.7652975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05150769488433662,"score_gpt":0.3502980621187126,"score_spread":0.2987903672343759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}