{"id":"W2080430705","doi":"10.1158/1535-7163.targ-11-b24","title":"Abstract B24: Detection of O6- and N7-methylguanine adducts by LC/MS in brain tumor tissues obtained from patients treated with temozolomide.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Université de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Temozolomide; O-6-methylguanine-DNA methyltransferase; Cancer; Medicine; Guanine; Cancer research; Regimen; Adduct; Radiation therapy; Methylation; DNA; Glioblastoma; Oncology; Chemistry; Internal medicine; Methyltransferase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960452,0.0006297607,0.0003043828,0.001511327,0.0003635187,0.0002459968,0.0002820612,0.0005747158,0.002964948],"category_scores_gemma":[0.0003461262,0.0001427555,0.0001854859,0.0005114872,0.0002074408,0.0001274894,0.0001702205,0.0003649392,0.001509601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936983,"about_ca_system_score_gemma":0.0002360462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002135582,"about_ca_topic_score_gemma":0.002572229,"domain_scores_codex":[0.9998399,0.00001815127,0.00001301649,0.00004887621,0.00005222615,0.00002789627],"domain_scores_gemma":[0.999841,0.00003747994,0.00003124851,0.00000995458,0.000041191,0.00003909713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006069702,0.00006091522,0.00393541,0.00007165046,0.00003539193,0.0003724493,0.00004218545,0.00003747885,0.9871106,0.00001509694,0.0004774859,0.007234348],"study_design_scores_gemma":[0.00005582769,0.001338391,0.1006142,0.00001942024,0.0001079089,0.003549017,0.00007290141,0.0007895809,0.8880073,0.00009146816,0.00532876,0.000025357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969708,0.006336364,0.008212632,0.0004083923,0.0002632914,0.0001980174,0.01003463,0.000694757,0.004143904],"genre_scores_gemma":[0.9584408,0.003034738,0.01636488,0.0005453252,0.0001140554,0.000208792,0.01395241,0.0001649708,0.007174064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002964948,"threshold_uncertainty_score":0.009918749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05150769488433662,"score_gpt":0.3502980621187126,"score_spread":0.2987903672343759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}