{"id":"W2080462728","doi":"10.1021/acschembio.5b00004","title":"A Small Molecule That Inhibits OGT Activity in Cells","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":290,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Glycosyltransferase; Small molecule; Transferase; Kinase; Intracellular; Chemical biology; High-throughput screening; Biochemistry; Glycan; Phosphatase; Cytoplasm; Enzyme; Cell biology; Drug discovery; Biology; Chemistry; Cell; Glycoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385291,0.0001441383,0.000167087,0.0000583283,0.00001706377,0.00001197721,0.000230956,0.0003561593,0.00002030208],"category_scores_gemma":[0.0002330828,0.0001307671,0.00005162234,0.000135687,0.0001279719,0.000003099583,0.0002726747,0.0002061144,0.00007147487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000325001,"about_ca_system_score_gemma":0.0001039691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008903466,"about_ca_topic_score_gemma":0.00006056329,"domain_scores_codex":[0.9988828,0.0001105957,0.0001372823,0.0004058069,0.00009012021,0.00037337],"domain_scores_gemma":[0.9993921,0.00002053886,0.00004354644,0.0002933715,0.00007367972,0.0001767924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813271,0.0000917725,0.002194883,0.000005681011,0.000009366582,0.000004773289,0.00001980251,0.000002631117,0.9943975,0.0000486514,0.000776978,0.002266613],"study_design_scores_gemma":[0.0009313737,0.0001546383,0.0001598709,0.000003982625,0.000001851567,0.000007242858,0.00001602945,0.000034628,0.9838863,0.0001825834,0.01446791,0.0001536023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995917,0.0001932829,0.0002436745,0.0003962945,0.00006475615,0.0001972485,0.0000121945,0.00001405936,0.002961461],"genre_scores_gemma":[0.9987242,0.00004000993,0.0002913207,0.0003255557,0.00009268929,0.00003857397,0.0001115348,0.00001455581,0.0003615685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01369093,"threshold_uncertainty_score":0.5332528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05065461219914576,"score_gpt":0.2928942514653514,"score_spread":0.2422396392662056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}