{"id":"W2080518844","doi":"10.1158/1078-0432.ccr-07-0701","title":"Human Breast Cancer Cells Selected for Resistance to Trastuzumab <i>In vivo</i> Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":506,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Trastuzumab; Gefitinib; Lapatinib; Erlotinib; Cancer research; Epidermal growth factor receptor; ErbB; In vivo; Epidermal growth factor; Growth factor receptor; Biology; Cancer; Receptor; Medicine; Breast cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293722,0.0003260893,0.0003554881,0.0001680138,0.0001664771,0.0003453982,0.0002172447,0.0002286686,0.0025151],"category_scores_gemma":[0.0001608868,0.0001711537,0.0002443493,0.0003381744,0.0001601712,0.0001496271,0.0001530038,0.0005305874,0.00112948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003206564,"about_ca_system_score_gemma":0.0002297458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001645104,"about_ca_topic_score_gemma":0.001368639,"domain_scores_codex":[0.9997923,0.00002826615,0.00002471972,0.00003783782,0.00006886,0.0000480296],"domain_scores_gemma":[0.9998798,0.00002702914,0.00002743461,0.00002875981,0.00002006575,0.00001697648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002996914,0.0001781708,0.003665048,0.00006351378,0.00002526187,0.0001976912,0.00004523754,0.00009048021,0.9911962,0.0001422078,0.0003031469,0.003793422],"study_design_scores_gemma":[0.0001156973,0.001633941,0.03108315,0.00001100383,0.00008805179,0.003226685,0.00007590857,0.0008834986,0.9548295,0.00004801119,0.007994322,0.00001023055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931774,0.001695427,0.001481091,0.00008827243,0.00002442337,0.00009057586,0.0009949676,0.00007831118,0.00236961],"genre_scores_gemma":[0.9860838,0.001551487,0.003200153,0.0001001681,0.00001855778,0.000104319,0.004537757,0.00003288213,0.004370875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025151,"threshold_uncertainty_score":0.008413851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1265625171483836,"score_gpt":0.4760326595411657,"score_spread":0.3494701423927821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}