{"id":"W2080530421","doi":"10.1371/journal.ppat.1000483","title":"Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA (PA3885)","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":341,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Army Research Office; Institute of Genetics; National Institute of Biomedical Imaging and Bioengineering; Japan Society for the Promotion of Science; National Institutes of Health","keywords":"Biofilm; Swarming motility; Quorum sensing; Mutant; Pseudomonas aeruginosa; Phosphatase; Operon; Periplasmic space; Biology; Biochemistry; Chemistry; Microbiology; Cell biology; Gene; Bacteria; Escherichia coli; Phosphorylation; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008498243,0.00033432,0.0001557018,0.000163883,0.0001248952,0.0002298615,0.0001580929,0.0002555813,0.0007594527],"category_scores_gemma":[0.0001029833,0.0001617884,0.0001758679,0.0001194264,0.0002099503,0.0002144706,0.0003231243,0.0004662128,0.0002595925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003187195,"about_ca_system_score_gemma":0.0002123064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143516,"about_ca_topic_score_gemma":0.001120151,"domain_scores_codex":[0.9999012,0.00001314086,0.000005950896,0.00001955863,0.00003876248,0.00002145716],"domain_scores_gemma":[0.9999518,0.000007031282,0.0000168045,0.000004410958,0.000006741635,0.0000131616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002125813,0.000008181275,0.0002427093,0.00001137017,0.000001214709,0.00002934514,0.000005192019,0.000030886,0.9991046,0.00003693687,0.000008648289,0.000499718],"study_design_scores_gemma":[0.000009703333,0.0001414142,0.01213136,0.00000378378,0.000008561755,0.0002568169,0.00004112203,0.001821977,0.9844946,0.0001385603,0.000947532,0.000004493766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996636,0.0007437437,0.001588086,0.0001540586,0.000007673088,0.00001204099,0.000159339,0.00003538876,0.0006636209],"genre_scores_gemma":[0.997072,0.0002747066,0.001274708,0.00005258535,0.000002074652,0.00001329359,0.0001618997,0.000006566386,0.001142078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143516,"threshold_uncertainty_score":0.002540648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149539545474354,"score_gpt":0.2360272813346689,"score_spread":0.2210733267872335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}