{"id":"W2080541487","doi":"10.1021/bi010903k","title":"Temperature Dependence of Dynamics and Thermodynamics of the Regulatory Domain of Human Cardiac Troponin C","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Alberta; Université de Sherbrooke","funders":"","keywords":"Conformational entropy; Chemistry; Troponin C; Heat capacity; Amide; Biophysics; Crystallography; Troponin; Thermodynamics; Biochemistry; Physics; Biology; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351276,0.00009738975,0.0003242138,0.00001576811,0.00003977729,0.000001585055,0.00007863471,0.0001181816,0.000003543346],"category_scores_gemma":[0.00003381382,0.00006948814,0.0001467762,0.0001109637,0.0003665243,0.0000101108,0.00007963738,0.0001093054,4.162691e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003763837,"about_ca_system_score_gemma":0.00005538097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001910308,"about_ca_topic_score_gemma":0.000004052548,"domain_scores_codex":[0.9993638,0.00001905589,0.0002011374,0.0001329361,0.000192649,0.00009042057],"domain_scores_gemma":[0.9993429,0.00002194152,0.0001284714,0.0003769633,0.00009981621,0.0000299206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005845259,0.00003703522,0.05556399,0.0002929792,0.0000967791,0.000003430266,0.0001613819,6.93453e-7,0.9429942,0.000468928,0.00007496643,0.0002471993],"study_design_scores_gemma":[0.000529681,0.00005712763,0.1977278,0.0002881073,0.0001605915,0.00005819315,0.001611865,0.00001914626,0.7992989,0.0001376269,0.00002270042,0.00008827349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935144,0.002412333,0.000004432869,0.00007070079,0.00004927309,0.0001041125,0.00006020919,0.000006309055,0.003778295],"genre_scores_gemma":[0.9991241,0.0001951053,0.00007940881,0.00000978969,0.00004996127,0.000002936487,0.00001013838,0.000008790494,0.0005197681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1436953,"threshold_uncertainty_score":0.2833644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004710741113642003,"score_gpt":0.2276069891762684,"score_spread":0.2228962480626264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}