{"id":"W2080576224","doi":"10.1002/cbic.200900108","title":"Development of New and Selective <i>Trypanosoma cruzi</i> trans‐Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Sulfonamide; Chalcone; Chemistry; Catechol; Sialidase; Trypanosoma cruzi; Stereochemistry; Non-competitive inhibition; Lactose; Hydrolysis; Enzyme; Biochemistry; Neuraminidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000008496438,0.0001864357,0.0003164535,0.00007646054,0.00009150017,0.00002213393,0.00006925672,0.0000956358,0.00002825956],"category_scores_gemma":[0.00009368156,0.0001515347,0.00004624562,0.0002151635,0.000153822,0.0000869889,0.00003358936,0.0001381524,0.000002110967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003925347,"about_ca_system_score_gemma":0.0002490378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000226985,"about_ca_topic_score_gemma":0.00001118389,"domain_scores_codex":[0.9990003,0.00001241962,0.0002725485,0.000319051,0.0001540128,0.000241743],"domain_scores_gemma":[0.9992784,0.000068286,0.00006821636,0.0001926124,0.00009723846,0.0002952238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001429205,0.0001143361,0.0003322447,0.00003003892,0.00006795058,0.000001771308,0.004934633,1.653663e-8,0.9491627,0.0001264832,0.0007144153,0.04437245],"study_design_scores_gemma":[0.0009896709,0.0001306186,0.2710743,0.00007405888,0.00001256547,0.00001285186,0.0007219146,0.000003401227,0.7223569,0.0005043143,0.004014042,0.0001054388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934129,0.001944223,0.0003328999,0.002303197,0.00001445255,0.0003122109,0.00002821616,0.00004048438,0.001611423],"genre_scores_gemma":[0.9947982,0.000195454,0.004320064,0.0002190139,0.000117125,0.00001186352,0.00005580693,0.0000135733,0.0002689009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.270742,"threshold_uncertainty_score":0.6179407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02533751578927077,"score_gpt":0.2777804192206386,"score_spread":0.2524429034313678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}