{"id":"W2080576224","doi":"10.1002/cbic.200900108","title":"Development of New and Selective <i>Trypanosoma cruzi</i> trans‐Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Sulfonamide; Chalcone; Chemistry; Catechol; Sialidase; Trypanosoma cruzi; Stereochemistry; Non-competitive inhibition; Lactose; Hydrolysis; Enzyme; Biochemistry; Neuraminidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224146,0.0004935342,0.0003936797,0.0002071309,0.00009773963,0.000237188,0.0003429444,0.0002363124,0.001206486],"category_scores_gemma":[0.0001247888,0.000146369,0.0001802351,0.0002017267,0.0002018219,0.0001904743,0.0001270037,0.0003976086,0.0004353495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232519,"about_ca_system_score_gemma":0.0002113235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006970118,"about_ca_topic_score_gemma":0.001953319,"domain_scores_codex":[0.9999303,0.00001560002,0.000006799355,0.0000113246,0.00001933033,0.00001672495],"domain_scores_gemma":[0.9999086,0.00001458548,0.00002375493,0.000005800991,0.00002137295,0.00002594345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002359414,0.0000655675,0.0002066007,0.0001624603,0.00001289928,0.0001055528,0.00002164105,0.0003361395,0.9897313,0.0001643321,0.0001342584,0.008823388],"study_design_scores_gemma":[0.0001198473,0.002284003,0.001929587,0.00001518374,0.00003781979,0.0004767175,0.00001852044,0.0005910158,0.9876602,0.00004503031,0.006809979,0.00001210969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724284,0.01437525,0.006582255,0.000180536,0.00006333145,0.0001999146,0.0006715228,0.0002649285,0.005233856],"genre_scores_gemma":[0.981804,0.007823845,0.005668813,0.0001121368,0.00002904676,0.00008604425,0.00124009,0.0000267004,0.00320934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206486,"threshold_uncertainty_score":0.004036129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02533751578927077,"score_gpt":0.2777804192206386,"score_spread":0.2524429034313678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}