{"id":"W2080581483","doi":"10.1002/cbic.201490065","title":"Inside Back Cover: An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases (ChemBioChem 18/2014)","year":2014,"lang":"en","type":"paratext","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Polyketide; Chemistry; Substrate (aquarium); Substrate specificity; Polyketide synthase; Stereochemistry; Cover (algebra); Phylogenetic tree; Biocatalysis; Biology; Biochemistry; Biosynthesis; Enzyme; Reaction mechanism; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004199686,0.0008451602,0.001604431,0.0002309219,0.0001557349,0.00009615807,0.0003197475,0.0009725702,0.002198989],"category_scores_gemma":[0.000305009,0.0007467198,0.0002717739,0.000288316,0.000557846,0.0002990655,0.0002240388,0.0009664115,0.0006513133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373066,"about_ca_system_score_gemma":0.0006322472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002161349,"about_ca_topic_score_gemma":0.000007118864,"domain_scores_codex":[0.9966186,0.00009478681,0.0008357444,0.001371416,0.0004755674,0.0006038673],"domain_scores_gemma":[0.9968853,0.000193613,0.0007154762,0.001247346,0.0005297631,0.000428532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000834369,0.0004823712,0.00005774364,0.0014416,0.0001420026,0.000011028,0.00005648419,0.0000125668,0.7709503,0.000009674413,0.2246265,0.001375309],"study_design_scores_gemma":[0.000783071,0.0002648304,0.0003357241,0.001303054,0.0003279164,0.0001466485,0.00004721067,0.0009274517,0.9786283,0.00003836996,0.01643397,0.0007635058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604397,0.008870001,0.00003428605,0.0004556658,0.0006078997,0.0006485209,0.0004164037,0.00006193375,0.02846559],"genre_scores_gemma":[0.9712948,0.002828396,0.002045606,0.0003061666,0.001064131,0.000002649766,0.001201722,0.0001174392,0.02113904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2081926,"threshold_uncertainty_score":0.9994984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03757613506407006,"score_gpt":0.2771083265609245,"score_spread":0.2395321914968544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}