{"id":"W2080581483","doi":"10.1002/cbic.201490065","title":"Inside Back Cover: An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases (ChemBioChem 18/2014)","year":2014,"lang":"en","type":"paratext","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Polyketide; Chemistry; Substrate (aquarium); Substrate specificity; Polyketide synthase; Stereochemistry; Cover (algebra); Phylogenetic tree; Biocatalysis; Biology; Biochemistry; Biosynthesis; Enzyme; Reaction mechanism; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551297,0.0005402067,0.0003761682,0.0006342055,0.0006728272,0.00285631,0.0006445675,0.001587301,0.07974894],"category_scores_gemma":[0.0004488157,0.0003905394,0.0003939038,0.0005534714,0.001231725,0.003529748,0.0009283764,0.002157178,0.02996553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001290669,"about_ca_system_score_gemma":0.0003496217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116735,"about_ca_topic_score_gemma":0.002427152,"domain_scores_codex":[0.9998711,0.00001644914,0.000004937464,0.00002657385,0.000062357,0.00001858472],"domain_scores_gemma":[0.9998888,0.00002853585,0.00001346537,0.00001631252,0.00002219836,0.00003075077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002079434,0.00006647285,0.0001865355,0.0003856026,0.00001588857,0.0005516795,0.00009488727,0.001556749,0.01509529,0.05828118,0.7894028,0.134155],"study_design_scores_gemma":[0.00002365265,0.0000773625,0.0005895605,0.0001062124,0.00001145334,0.0004320872,0.00006196247,0.001306947,0.005396448,0.02813291,0.9638412,0.00002027566],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.01264278,0.0724998,0.04609441,0.1028517,0.05369487,0.000174086,0.003511092,0.003203518,0.7053277],"genre_scores_gemma":[0.08547892,0.0469802,0.01766298,0.02299273,0.009035904,0.000152108,0.002955496,0.0008983841,0.8138433],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.07974894,"threshold_uncertainty_score":0.2667868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03757613506407006,"score_gpt":0.2771083265609245,"score_spread":0.2395321914968544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}