{"id":"W2080601632","doi":"10.1371/journal.pone.0068916","title":"Quantifying Biomass Changes of Single CD8+ T Cells during Antigen Specific Cytotoxicity","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for AIDS Research, University of California Los Angeles; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Cancer Institute; Center for AIDS Research, University of Washington; Howard Hughes Medical Institute","keywords":"Cytotoxic T cell; Mass cytometry; Single-cell analysis; Flow cytometry; CD8; Population; Cytotoxicity; Cell biology; T cell; Cell; Intracellular; Antigen-presenting cell; Chemistry; Biology; Antigen; Molecular biology; Immunology; Immune system; In vitro; Phenotype; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004241329,0.0004836907,0.0003620738,0.0006462479,0.0002971358,0.0005430655,0.000369401,0.0005092014,0.001050999],"category_scores_gemma":[0.0005839788,0.0002495428,0.0001916397,0.0005243104,0.0003368955,0.0005676437,0.0003812688,0.0008810062,0.0003722727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005357384,"about_ca_system_score_gemma":0.0002894339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004595842,"about_ca_topic_score_gemma":0.0009243974,"domain_scores_codex":[0.9995729,0.00005756048,0.00002265637,0.0001103998,0.00017138,0.00006507782],"domain_scores_gemma":[0.9996834,0.0001161444,0.00007455928,0.0000299261,0.00006582647,0.00003014732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005776088,0.00001351901,0.0005055767,0.00002733815,0.00000309938,0.00001985504,0.00006586436,0.0002048696,0.9960658,0.00006813481,0.00002452879,0.002943715],"study_design_scores_gemma":[0.000007582412,0.0001698676,0.004848949,0.000005708465,0.00001152754,0.00006580835,0.00007888798,0.005121994,0.9888545,0.0001742927,0.0006522015,0.000008678187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455373,0.001153521,0.05032255,0.00009497557,0.00004780037,0.00008807577,0.0004863317,0.0003394333,0.001930019],"genre_scores_gemma":[0.9497758,0.001117682,0.04502683,0.0001189119,0.0000262462,0.0003347664,0.0005724781,0.0000834892,0.00294372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050999,"threshold_uncertainty_score":0.003887117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.166712184824173,"score_gpt":0.2961743190881353,"score_spread":0.1294621342639623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}