{"id":"W2080601632","doi":"10.1371/journal.pone.0068916","title":"Quantifying Biomass Changes of Single CD8+ T Cells during Antigen Specific Cytotoxicity","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for AIDS Research, University of California Los Angeles; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Cancer Institute; Center for AIDS Research, University of Washington; Howard Hughes Medical Institute","keywords":"Cytotoxic T cell; Mass cytometry; Single-cell analysis; Flow cytometry; CD8; Population; Cytotoxicity; Cell biology; T cell; Cell; Intracellular; Antigen-presenting cell; Chemistry; Biology; Antigen; Molecular biology; Immunology; Immune system; In vitro; Phenotype; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001934745,0.0001555198,0.0004485409,0.0002540865,0.00006742647,0.00003260457,0.0001538839,0.0001002346,0.005907608],"category_scores_gemma":[0.000041153,0.0001452541,0.00008007889,0.0003418562,0.0001190715,0.00008233063,0.00009620659,0.0001870638,0.0003721367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016743,"about_ca_system_score_gemma":0.0000267445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001704706,"about_ca_topic_score_gemma":0.00002814794,"domain_scores_codex":[0.998287,0.00005359343,0.0002558849,0.0003008513,0.0006727726,0.0004299438],"domain_scores_gemma":[0.9989384,0.00008220884,0.00009449323,0.0004988796,0.0002175913,0.0001684684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066221,0.00158138,0.01557804,0.0005697125,0.0002138756,0.00002072454,0.0003295536,1.55464e-7,0.9810087,0.000003961972,0.00009281125,0.0004944669],"study_design_scores_gemma":[0.00081365,0.0003113634,0.02988829,0.0003687803,0.00002404734,0.000004803295,0.0001272585,0.0000562461,0.9680752,0.000009462311,0.000188622,0.0001323315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954202,0.0006003216,0.00000873378,0.0005526663,0.00004009649,0.0008879706,0.000009073729,0.00008141529,0.0023995],"genre_scores_gemma":[0.9944211,0.0007734636,0.001338024,0.00003207031,0.0002933382,0.00003184623,0.000008961233,0.00005072632,0.003050434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01431025,"threshold_uncertainty_score":0.9950011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.166712184824173,"score_gpt":0.2961743190881353,"score_spread":0.1294621342639623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}