{"id":"W2080612183","doi":"10.4161/auto.26059","title":"Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling","year":2013,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; China Scholarship Council; National Natural Science Foundation of China","keywords":"Sequestosome 1; Biology; Autophagy; Cleavage (geology); Cell biology; Signal transduction; Protease; Biochemistry; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193297,0.0005580606,0.0003315326,0.0002678866,0.0001622784,0.0003100989,0.000271522,0.0005805204,0.001038327],"category_scores_gemma":[0.0001681928,0.0002724493,0.0004571479,0.0001842506,0.0003971788,0.0002656162,0.0002226145,0.0009096586,0.0003114954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004461297,"about_ca_system_score_gemma":0.0002172942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000910465,"about_ca_topic_score_gemma":0.0006593667,"domain_scores_codex":[0.99975,0.00003094134,0.00004626573,0.00005190938,0.00005300919,0.00006789191],"domain_scores_gemma":[0.9998006,0.00002656645,0.00006470161,0.00002533254,0.000009764868,0.00007301349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002616083,0.00006407899,0.0001529116,0.00002072341,0.000009481634,0.000187316,0.00001363513,0.00006615754,0.9987674,0.00009117134,0.0000237858,0.0003417701],"study_design_scores_gemma":[0.00006252329,0.0004670328,0.00883475,0.000007804332,0.0000258726,0.001239803,0.00004635355,0.002349272,0.9858854,0.0001278014,0.0009414643,0.0000120166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978855,0.000363366,0.00100996,0.00004668487,0.00002143736,0.00001100367,0.0002822227,0.00006290428,0.0003168552],"genre_scores_gemma":[0.9976865,0.0001720338,0.0007442913,0.00003120813,0.000004005853,0.0000187146,0.0004424602,0.00001610008,0.000884666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038327,"threshold_uncertainty_score":0.00347352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079821847431653,"score_gpt":0.2695678153680963,"score_spread":0.2587695968937798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}