{"id":"W2080613214","doi":"10.1074/jbc.m403184200","title":"Oxidative Stress Activates the Plasminogen Activator Inhibitor Type 1 (PAI-1) Promoter through an AP-1 Response Element and Cooperates with Insulin for Additive Effects on PAI-1 Transcription","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; York University; Diabetes Action Research and Education Foundation; National Science Foundation","keywords":"Oxidative stress; Response element; Transcription factor; Plasminogen activator inhibitor-1; Activator (genetics); Plasminogen activator; Insulin; Endocrinology; Electrophoretic mobility shift assay; Transcription (linguistics); Oxidative phosphorylation; Internal medicine; Chemistry; Promoter; Molecular biology; Biology; Biochemistry; Gene expression; Receptor; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002343616,0.0006178587,0.0003425125,0.0004256413,0.0001788025,0.0003204275,0.0002204997,0.0002607042,0.001661955],"category_scores_gemma":[0.0002048062,0.0002074679,0.0005638634,0.0002357316,0.0002732971,0.0003075246,0.0003365988,0.0007876817,0.0004717273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002899722,"about_ca_system_score_gemma":0.0002077818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002536862,"about_ca_topic_score_gemma":0.0003336132,"domain_scores_codex":[0.9997205,0.00003548007,0.00001785683,0.00007268329,0.0000955443,0.00005786434],"domain_scores_gemma":[0.9997796,0.00004134573,0.00006359278,0.00001904584,0.00003549456,0.00006084986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149075,0.0000451957,0.0001963491,0.00005972891,0.000007699298,0.00004292489,0.00001774043,0.00001501721,0.998171,0.00006354381,0.00003141237,0.001234474],"study_design_scores_gemma":[0.00003325117,0.0005083993,0.009612664,0.00001600112,0.00003554968,0.0004931696,0.00004121173,0.0006220309,0.9848298,0.0002267406,0.003571238,0.000009995329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761905,0.007911995,0.01228599,0.0004262436,0.0002182216,0.00006359308,0.0004434513,0.0001728128,0.002287152],"genre_scores_gemma":[0.9829127,0.003676724,0.008008157,0.0001754927,0.00009609714,0.00006557932,0.0008710664,0.00002166346,0.004172663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001661955,"threshold_uncertainty_score":0.005559802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277195347801373,"score_gpt":0.2797486742876455,"score_spread":0.2520291395075082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}