{"id":"W2080613214","doi":"10.1074/jbc.m403184200","title":"Oxidative Stress Activates the Plasminogen Activator Inhibitor Type 1 (PAI-1) Promoter through an AP-1 Response Element and Cooperates with Insulin for Additive Effects on PAI-1 Transcription","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; York University; Diabetes Action Research and Education Foundation; National Science Foundation","keywords":"Oxidative stress; Response element; Transcription factor; Plasminogen activator inhibitor-1; Activator (genetics); Plasminogen activator; Insulin; Endocrinology; Electrophoretic mobility shift assay; Transcription (linguistics); Oxidative phosphorylation; Internal medicine; Chemistry; Promoter; Molecular biology; Biology; Biochemistry; Gene expression; Receptor; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003252635,0.0002413566,0.000390392,0.00002367156,0.0001471239,0.00003293661,0.0001033313,0.000189338,0.00004193479],"category_scores_gemma":[0.0005402925,0.000117107,0.00008451502,0.0001192677,0.0002567816,0.000272188,0.00001835457,0.0004568429,8.579245e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078679,"about_ca_system_score_gemma":0.0001457785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002586718,"about_ca_topic_score_gemma":0.000001058757,"domain_scores_codex":[0.998883,0.0001559674,0.0002683098,0.0002595673,0.0002128824,0.0002202797],"domain_scores_gemma":[0.998506,0.0006634503,0.0002846542,0.0001200093,0.0002983189,0.0001275613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03536858,0.0006963797,0.0006349797,0.00009493136,0.0002174985,0.00004737615,0.0006294674,0.000007768806,0.9609208,0.00001975896,0.00005359304,0.001308934],"study_design_scores_gemma":[0.003755503,0.01048817,0.01043161,0.0006275805,0.00008862685,0.0001145428,0.001276343,0.00000413146,0.972247,0.0001309888,0.0006758213,0.000159653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973311,0.0001512739,0.0004453837,0.001327239,0.00003973804,0.0005246641,0.0001159097,0.00001552157,0.00004916183],"genre_scores_gemma":[0.9980497,0.0002035925,0.001005399,0.0002546152,0.0003674421,0.00002626341,0.00004904672,0.00001463765,0.00002931939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03161308,"threshold_uncertainty_score":0.4775485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277195347801373,"score_gpt":0.2797486742876455,"score_spread":0.2520291395075082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}