{"id":"W2080629063","doi":"10.1172/jci63765","title":"Compromised genomic integrity impedes muscle growth after Atrx inactivation","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Ottawa; McMaster University Medical Centre; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"ATRX; Biology; Skeletal muscle; Cell biology; Chromatin; Genetics; Anatomy; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478187,0.0003153993,0.0002595499,0.0003091635,0.0001197294,0.0002219071,0.0002280059,0.0003341741,0.001493999],"category_scores_gemma":[0.0002134984,0.0002206369,0.0001912394,0.00009644769,0.0003325653,0.0002321534,0.0003954238,0.0006004866,0.0003459951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489055,"about_ca_system_score_gemma":0.000141319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003619308,"about_ca_topic_score_gemma":0.000683573,"domain_scores_codex":[0.999846,0.0000263401,0.00001971817,0.00004322676,0.00004164215,0.00002319276],"domain_scores_gemma":[0.9997898,0.00006156154,0.00007097999,0.00002412229,0.00001101939,0.00004255282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004419909,0.00001280787,0.0002102115,0.00001640593,0.00000472745,0.0001556616,0.00001110958,0.00004314422,0.9987652,0.00007865209,0.00001568199,0.0006421746],"study_design_scores_gemma":[0.00001565458,0.0003469837,0.0087331,0.0000112576,0.00001786093,0.001684924,0.00003280084,0.0008048057,0.9869007,0.00008532055,0.0013625,0.000004059298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946014,0.001105952,0.002912928,0.00006739931,0.00002125636,0.00001818127,0.0001930755,0.0001232005,0.000956656],"genre_scores_gemma":[0.9959003,0.0006976444,0.001225539,0.00003472811,0.000006871527,0.00001992334,0.000307565,0.0000320267,0.001775374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493999,"threshold_uncertainty_score":0.004997909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05117976661273109,"score_gpt":0.3287129231598622,"score_spread":0.2775331565471311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}