{"id":"W2080666240","doi":"10.1073/pnas.0809632106","title":"Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; York University; Howard Hughes Medical Institute","keywords":"Dephosphorylation; Biology; Integrated stress response; Phosphorylation; Cell biology; Translation (biology); eIF2; Phosphatase; Mutant; Protein subunit; Gene; Genetics; Messenger RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878406,0.0004044183,0.0002825678,0.0002779849,0.0001212882,0.0003550558,0.0002514108,0.0003831142,0.001046125],"category_scores_gemma":[0.0001162176,0.000267789,0.000210522,0.0001243411,0.0003712617,0.0001749676,0.0003237996,0.0003647722,0.0006336135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182581,"about_ca_system_score_gemma":0.0002214909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003767461,"about_ca_topic_score_gemma":0.0006462449,"domain_scores_codex":[0.9998389,0.00002123204,0.00002443173,0.00004679902,0.00004909582,0.00001941267],"domain_scores_gemma":[0.9998394,0.00001900378,0.00007950117,0.00001482912,0.000005866386,0.00004132802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006020696,0.000006797388,0.0003788206,0.00002656533,0.000005817641,0.0002447951,0.000008958957,0.0000907254,0.9973726,0.0002792373,0.00003163016,0.001493808],"study_design_scores_gemma":[0.00004828732,0.000276412,0.02313428,0.00003343884,0.00005687304,0.004395347,0.00004027852,0.001569054,0.9649038,0.0003633793,0.005166577,0.0000123241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909464,0.002378836,0.004275896,0.0001218046,0.00002198945,0.00001681888,0.0004692177,0.0001711336,0.001597825],"genre_scores_gemma":[0.9917696,0.001503261,0.003864019,0.00006137071,0.000008350902,0.00001964274,0.0004562761,0.00005790409,0.002259532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046125,"threshold_uncertainty_score":0.003499627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141748089452146,"score_gpt":0.332239250097752,"score_spread":0.2908217692032305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}