{"id":"W2080668437","doi":"10.1006/prep.2000.1292","title":"Factor X Fusion Proteins: Improved Production and Use in the Release in Vitro of Biologically Active Hirudin from an Inactive α-Factor–Hirudin Fusion Protein","year":2000,"lang":"en","type":"article","venue":"Protein Expression and Purification","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; GLA University","keywords":"Fusion protein; Biochemistry; Protease; Recombinant DNA; Thrombin; Hirudin; Chemistry; Peptide; Biological activity; Biology; In vitro; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002146107,0.0001951491,0.0002043332,0.00007869882,0.0001288682,0.0000360868,0.0001201569,0.0002013579,0.00003090172],"category_scores_gemma":[0.0002500133,0.0001352951,0.0000314697,0.0001337064,0.0001144554,0.00006038835,0.00005374111,0.0001783746,0.000001172187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002675812,"about_ca_system_score_gemma":0.00002851908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005120366,"about_ca_topic_score_gemma":0.0002017618,"domain_scores_codex":[0.9984025,0.0004077572,0.0003409142,0.0005424221,0.0001404516,0.0001659882],"domain_scores_gemma":[0.9993646,0.00001903451,0.0002026515,0.0002868119,0.00007363811,0.0000532223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001844068,0.0002933709,0.0006117517,0.00002332238,0.000005486378,7.316791e-7,0.001085945,0.00000230852,0.9510443,0.00001325041,0.000003627775,0.04507183],"study_design_scores_gemma":[0.0006189742,0.0004442778,0.0940932,0.0001134675,0.000003771251,0.000001551494,0.0005795724,0.0001640139,0.9028423,0.0001615218,0.0008011356,0.0001762531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966978,0.0003813796,0.00009048992,0.0003765164,0.00001364704,0.0023043,0.00007035472,0.0000132552,0.00005223176],"genre_scores_gemma":[0.9976245,0.0003790353,0.0011145,0.00004428404,0.00005684925,0.0005375387,0.0001350016,0.00001269774,0.00009565019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09348144,"threshold_uncertainty_score":0.5517175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037398115706503,"score_gpt":0.251757267313994,"score_spread":0.231383286156929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}