{"id":"W2080668437","doi":"10.1006/prep.2000.1292","title":"Factor X Fusion Proteins: Improved Production and Use in the Release in Vitro of Biologically Active Hirudin from an Inactive α-Factor–Hirudin Fusion Protein","year":2000,"lang":"en","type":"article","venue":"Protein Expression and Purification","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; GLA University","keywords":"Fusion protein; Biochemistry; Protease; Recombinant DNA; Thrombin; Hirudin; Chemistry; Peptide; Biological activity; Biology; In vitro; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006423154,0.0006287645,0.0003925884,0.0003042865,0.0003252559,0.0005445716,0.0005048884,0.0004738033,0.000671915],"category_scores_gemma":[0.000434609,0.0002505503,0.0005162629,0.0003705215,0.0004195389,0.0005556528,0.0002820015,0.0009413097,0.0005228803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004596024,"about_ca_system_score_gemma":0.0002621788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135614,"about_ca_topic_score_gemma":0.0008297754,"domain_scores_codex":[0.9996854,0.00007133344,0.00003866116,0.00005726678,0.00009127663,0.00005611122],"domain_scores_gemma":[0.9997852,0.00005954313,0.0000463967,0.00003737106,0.00003426371,0.00003733886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131045,0.0000196964,0.0001090264,0.00002392109,0.00000654419,0.00005618746,0.00003476795,0.00005058678,0.9981923,0.0001615501,0.00004514518,0.001169256],"study_design_scores_gemma":[0.0000142844,0.00009623136,0.0004901144,0.000002347251,0.00001268244,0.0003551612,0.000008200417,0.0003496117,0.99661,0.00002963765,0.002026608,0.00000505189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9350497,0.003926086,0.05799127,0.0003077548,0.0001112472,0.0001620763,0.0006930362,0.0002674264,0.001491388],"genre_scores_gemma":[0.9517643,0.002530909,0.03433863,0.00008952857,0.00004814831,0.00007962099,0.003673832,0.0001469181,0.007328052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135614,"threshold_uncertainty_score":0.003396928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037398115706503,"score_gpt":0.251757267313994,"score_spread":0.231383286156929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}