{"id":"W2080681527","doi":"10.1038/cddis.2012.149","title":"Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor","year":2012,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; Leukemia and Lymphoma Society; Canadian Institutes of Health Research; Susan G. Komen; Cancer Therapeutics Cooperative Research Centre","keywords":"Translation (biology); Programmed cell death; Homoharringtonine; Apoptosis; Cytotoxicity; Biology; Cancer research; Myeloid leukemia; Clonogenic assay; Cytotoxic T cell; Cell biology; In vitro; Biochemistry; Messenger RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003344396,0.0005248807,0.0004504854,0.0003591917,0.0002217265,0.0005939764,0.0001811312,0.0003368894,0.002081897],"category_scores_gemma":[0.0001956624,0.0001373494,0.0003984352,0.0001616239,0.0003167979,0.0003487146,0.0002942774,0.0007220054,0.0007524352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584698,"about_ca_system_score_gemma":0.0002367054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002195735,"about_ca_topic_score_gemma":0.000361669,"domain_scores_codex":[0.9995577,0.00007738535,0.00003970448,0.00008666683,0.0001539096,0.00008464208],"domain_scores_gemma":[0.9997223,0.00006610463,0.00007501589,0.00005107454,0.00005902845,0.00002653926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001199933,0.00003155868,0.0003060779,0.0001158106,0.00001563762,0.00008926643,0.0000198855,0.00006496359,0.9924224,0.0003903282,0.0001163242,0.006307786],"study_design_scores_gemma":[0.00001128866,0.0004434262,0.002724428,0.000009214882,0.00001874454,0.0003617198,0.0000209685,0.000270761,0.9908077,0.0001382299,0.005189859,0.000003597813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9354237,0.03233676,0.01973614,0.0009695299,0.0002350796,0.0002005883,0.0005710835,0.0005720554,0.009954996],"genre_scores_gemma":[0.9853308,0.00529776,0.002767558,0.000234435,0.00004934992,0.00007703062,0.0003002071,0.00003386783,0.005909044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002081897,"threshold_uncertainty_score":0.006964624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009288568604410586,"score_gpt":0.2143651879635835,"score_spread":0.2050766193591729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}