{"id":"W2080740378","doi":"10.1111/febs.12371","title":"Structural and functional importance of local and global conformational fluctuations in the <scp>RN</scp>ase <scp>A</scp> superfamily","year":2013,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Institut National de la Recherche Scientifique","funders":"","keywords":"Protein superfamily; RNase P; Structural motif; Computational biology; Protein dynamics; Structural similarity; SUPERFAMILY; Function (biology); Protein structure; Flexibility (engineering); Molecular dynamics; Globular protein; Evolutionary biology; Biology; Chemistry; Genetics; Biochemistry; RNA; Computational chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329248,0.0002586564,0.0003022616,0.000322753,0.0002023103,0.0005087434,0.0002418689,0.0003637806,0.0008001968],"category_scores_gemma":[0.0002571719,0.0001559749,0.0002774923,0.0003005284,0.0003498689,0.0003684574,0.0002553582,0.0004506718,0.0004385516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634226,"about_ca_system_score_gemma":0.0002026062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002910852,"about_ca_topic_score_gemma":0.0002983598,"domain_scores_codex":[0.9999087,0.0000144172,0.000009232454,0.00003106168,0.00002289493,0.00001382163],"domain_scores_gemma":[0.9998851,0.00004204671,0.00003768842,0.000006148241,0.0000132735,0.00001577098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001545413,0.00003408474,0.003786345,0.003720041,0.0001097204,0.001066567,0.0006395367,0.003019847,0.7722034,0.007769808,0.004275115,0.203221],"study_design_scores_gemma":[0.00002921794,0.001234689,0.116923,0.0008643061,0.0004455746,0.01114988,0.001148111,0.008694069,0.3543582,0.009794862,0.4951798,0.0001781446],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4402329,0.5186251,0.01830357,0.001389632,0.0008755638,0.00004995494,0.0005390186,0.0005023602,0.0194819],"genre_scores_gemma":[0.6550901,0.3254112,0.007613667,0.000604149,0.001057418,0.00009697116,0.001124687,0.0001038201,0.008898049],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008001968,"threshold_uncertainty_score":0.002676904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674902319714332,"score_gpt":0.2692657414581993,"score_spread":0.252516718261056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}