{"id":"W2080744941","doi":"10.1155/2013/793525","title":"Resveratrol Suppresses PAI-1 Gene Expression in a Human<i>In Vitro</i>Model of Inflamed Adipose Tissue","year":2013,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biocenter, University of Oulu; International Graduate School in Molecular Medicine Ulm; Universität Ulm; European Social Fund; Medizinischen Hochschule Hannover; Ottawa Hospital Research Institute","keywords":"Resveratrol; Adipose tissue; Plasminogen activator inhibitor-1; Inflammation; Downregulation and upregulation; Activator (genetics); Adipose tissue macrophages; AMPK; Chemistry; Endocrinology; Gene expression; Internal medicine; PI3K/AKT/mTOR pathway; White adipose tissue; Signal transduction; Cell biology; Plasminogen activator; Biology; Pharmacology; Gene; Medicine; Biochemistry; Phosphorylation; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007838025,0.000368946,0.001145488,0.0004697415,0.00006971771,0.0000100051,0.0001580805,0.0002265728,0.0005451496],"category_scores_gemma":[0.000388231,0.0002541505,0.00006859538,0.0003988823,0.000566889,0.0002077077,0.0001126067,0.0005783555,0.000007448806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006295022,"about_ca_system_score_gemma":0.00008062439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007388139,"about_ca_topic_score_gemma":0.00004456146,"domain_scores_codex":[0.9973262,0.0002365831,0.0008467418,0.000565981,0.0005706861,0.0004538332],"domain_scores_gemma":[0.9985188,0.000199072,0.0002316725,0.0005441727,0.0002043241,0.0003019914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003891367,0.0003318181,0.009606689,0.0003117405,0.00003728684,0.000155781,0.001654365,0.00002892065,0.9829587,0.00002882955,0.001278775,0.003217915],"study_design_scores_gemma":[0.007507378,0.0009071967,0.01018089,0.0009853021,0.0001251047,0.00002064077,0.0008406633,0.002199073,0.9761787,0.000331474,0.0004803989,0.0002431533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885861,0.005698665,0.001063743,0.001588875,0.00008363603,0.001181052,0.000009820809,0.00002615069,0.001761954],"genre_scores_gemma":[0.9959044,0.0006712298,0.001535927,0.0004759716,0.0002605983,0.0001093141,0.0001286112,0.00003581663,0.0008781225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007318304,"threshold_uncertainty_score":0.9999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358284755378728,"score_gpt":0.2771940668480385,"score_spread":0.2536112192942512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}