{"id":"W2080752129","doi":"10.1073/pnas.0805524105","title":"Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health","keywords":"Protein kinase R; EIF-2 kinase; Biology; Protein kinase A; Phosphorylation; Antiviral protein; Kinase; Protein kinase domain; Cell biology; Molecular biology; Mutant; Mitogen-activated protein kinase kinase; RNA; Biochemistry; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638839,0.0006311181,0.0002677142,0.0002548263,0.0002384403,0.0003509684,0.0004225113,0.0003936632,0.001097518],"category_scores_gemma":[0.0003090491,0.0002422552,0.0004599322,0.000278114,0.0003936364,0.0002174275,0.0002790353,0.0006381783,0.0007484294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004851771,"about_ca_system_score_gemma":0.0003402244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086213,"about_ca_topic_score_gemma":0.0008661028,"domain_scores_codex":[0.9997395,0.00006202681,0.00004673037,0.00003435359,0.00007215535,0.00004533099],"domain_scores_gemma":[0.9995943,0.0001098179,0.0001383023,0.00005990302,0.0000282009,0.00006941784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343813,0.00005504825,0.0001524911,0.00001781799,0.000009760644,0.000121074,0.00002354338,0.0001355031,0.9986621,0.0001575921,0.00003851073,0.0004921731],"study_design_scores_gemma":[0.00004064463,0.0003656674,0.002437421,0.000005217568,0.00002371511,0.0008700152,0.0000423319,0.001628021,0.9930753,0.00006481603,0.001436044,0.00001089794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956207,0.0002818608,0.002638072,0.00009769576,0.0000313522,0.0000453294,0.000417791,0.00007998852,0.000787271],"genre_scores_gemma":[0.9934682,0.0002969715,0.00321459,0.00005076597,0.00001114493,0.00005518366,0.0009288695,0.0001015018,0.001872894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001097518,"threshold_uncertainty_score":0.003671587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03489308787190384,"score_gpt":0.2873429088045021,"score_spread":0.2524498209325983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}