{"id":"W2080763661","doi":"10.1523/jneurosci.2557-08.2008","title":"Oxoguanine Glycosylase 1 Protects Against Methamphetamine-Enhanced Fetal Brain Oxidative DNA Damage and Neurodevelopmental Deficits","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Meth-; Offspring; In utero; Oxidative stress; Methamphetamine; Fetus; DNA damage; Lesion; Brain damage; Biology; Internal medicine; Endocrinology; Pharmacology; Medicine; Pregnancy; Pathology; Chemistry; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118465,0.0004937007,0.0002929363,0.0002923164,0.0001298382,0.0001749339,0.0002846593,0.0003563798,0.0009530336],"category_scores_gemma":[0.0001566171,0.0001782351,0.000170988,0.00008665163,0.0002124544,0.0001504222,0.0001903436,0.0005882008,0.000191038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842984,"about_ca_system_score_gemma":0.0002855318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009861473,"about_ca_topic_score_gemma":0.001775718,"domain_scores_codex":[0.9999216,0.00001009799,0.000008046813,0.0000222061,0.00001419822,0.00002378821],"domain_scores_gemma":[0.99983,0.00001331248,0.00007341692,0.00001799852,0.00001442951,0.00005081093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005322072,0.0001135626,0.0007841997,0.0000567853,0.0000138607,0.00007580711,0.00003061404,0.00006093143,0.9946127,0.00005116468,0.00004625334,0.003621983],"study_design_scores_gemma":[0.00003031257,0.001415026,0.01391536,0.00002255442,0.00003827241,0.000240859,0.00006068193,0.0003574434,0.9828116,0.00005003206,0.001053039,0.000004664219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971749,0.001301937,0.0008009318,0.00008881972,0.00001619026,0.00001318416,0.0001605776,0.0000605356,0.0003828822],"genre_scores_gemma":[0.9943976,0.001502282,0.0009996528,0.00005792364,0.00001039155,0.00003877818,0.0004453296,0.00001900601,0.002528958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009861473,"threshold_uncertainty_score":0.003188252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205881425157604,"score_gpt":0.2617714612125506,"score_spread":0.2397126469609745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}