{"id":"W2080786558","doi":"10.1021/bi051782h","title":"ERK Modulates DNA Bending and Enhancesome Structure by Phosphorylating HMG1-Boxes 1 and 2 of the RNA Polymerase I Transcription Factor UBF","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Université Laval; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Molecular biology; HMG-box; Transcription (linguistics); RNA polymerase II; RNA polymerase I; Biology; Transcription factor; MAPK/ERK pathway; Chromatin; DNA; Phosphorylation; Promoter; Cell biology; RNA polymerase; RNA; Gene expression; Gene; DNA-binding protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000711735,0.0002045204,0.00009132777,0.00008645075,0.00007504799,0.0001600513,0.0001488046,0.0001115117,0.00109846],"category_scores_gemma":[0.0001177678,0.00009478186,0.0001024033,0.00003814404,0.0001742505,0.0001118751,0.0001708523,0.0001838112,0.0001990466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001450627,"about_ca_system_score_gemma":0.0000740266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001978923,"about_ca_topic_score_gemma":0.0003881255,"domain_scores_codex":[0.9999516,0.000009355164,0.000002403613,0.000009402722,0.000009498401,0.00001771179],"domain_scores_gemma":[0.9999437,0.00001107597,0.00002076908,0.000005445853,0.000003953794,0.00001510308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002547789,0.00002785757,0.0003774671,0.0000168186,0.000003517216,0.00003524847,0.000008034282,0.0001805711,0.9976583,0.0001367938,0.00001940626,0.001281197],"study_design_scores_gemma":[0.00002406907,0.00009182261,0.008048922,0.000002998403,0.000008350825,0.0001277156,0.00001757991,0.002003244,0.9890035,0.00009905985,0.0005691972,0.000003530597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989377,0.0001379612,0.0003865102,0.00001731285,0.000003295401,0.000002590288,0.00002271917,0.000012638,0.0004792337],"genre_scores_gemma":[0.9991315,0.0001232469,0.0002050669,0.000008305311,0.000002277017,0.000002803501,0.0000371025,0.000005213147,0.0004845767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109846,"threshold_uncertainty_score":0.003674686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001960054181580104,"score_gpt":0.174428896170835,"score_spread":0.1724688419892549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}