{"id":"W2080786558","doi":"10.1021/bi051782h","title":"ERK Modulates DNA Bending and Enhancesome Structure by Phosphorylating HMG1-Boxes 1 and 2 of the RNA Polymerase I Transcription Factor UBF","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Université Laval; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Molecular biology; HMG-box; Transcription (linguistics); RNA polymerase II; RNA polymerase I; Biology; Transcription factor; MAPK/ERK pathway; Chromatin; DNA; Phosphorylation; Promoter; Cell biology; RNA polymerase; RNA; Gene expression; Gene; DNA-binding protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003100096,0.0001572681,0.0001197105,0.000008849823,0.0000970218,0.00002751295,0.0001094604,0.0001637621,0.000009342741],"category_scores_gemma":[0.0000120186,0.0001306405,0.00004877881,0.00004039073,0.0001118588,0.000003573303,0.00006120541,0.00007055034,6.203645e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001001126,"about_ca_system_score_gemma":0.00001921304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004546824,"about_ca_topic_score_gemma":0.00001032372,"domain_scores_codex":[0.9992967,0.00001092264,0.0001868987,0.0002680572,0.00008332163,0.0001541147],"domain_scores_gemma":[0.9996119,0.000006204759,0.0001225546,0.0001970059,0.00002255131,0.00003977807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009748426,0.00001299345,0.0035909,0.0000668184,0.00001752567,1.684975e-7,0.00003293529,0.00001006924,0.9953206,0.000009931201,0.000110279,0.000818011],"study_design_scores_gemma":[0.0002489197,0.00002215488,0.004659982,0.00002500057,0.00001636029,0.00000797668,0.00006578716,0.0002307787,0.9943755,0.0001093885,0.00008796487,0.0001502134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943787,0.004907269,0.00005331633,0.00004512209,0.00005485291,0.00007560779,0.0003892019,0.00000546335,0.00009040747],"genre_scores_gemma":[0.9990742,0.0001344366,0.0002349197,0.00002404086,0.00008844592,0.000002578316,0.0001406596,0.00001653098,0.0002842204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004772832,"threshold_uncertainty_score":0.5327366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001960054181580104,"score_gpt":0.174428896170835,"score_spread":0.1724688419892549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}