{"id":"W2080806128","doi":"10.1074/jbc.m808700200","title":"Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; McGill University","keywords":"Parkin; Ubiquitin ligase; Cysteine; Ubiquitin; RING finger domain; Ubiquitin-Protein Ligases; Chemistry; Peptide sequence; Ring finger; DNA ligase; Sequence alignment; Biology; Genetics; Biochemistry; Stereochemistry; Parkinson's disease; DNA; Enzyme; Zinc finger; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007836477,0.0002601852,0.0002036942,0.0001743331,0.0001206244,0.0001810695,0.0002296089,0.0003851391,0.0003976132],"category_scores_gemma":[0.0001705079,0.000103621,0.00020678,0.0001132486,0.0001837295,0.0001031814,0.0001811877,0.0001958968,0.0003244832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581533,"about_ca_system_score_gemma":0.00009335597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003729099,"about_ca_topic_score_gemma":0.0004398306,"domain_scores_codex":[0.9999409,0.000005604397,0.000006000038,0.00002181751,0.00001669794,0.000009085364],"domain_scores_gemma":[0.9998957,0.00001916837,0.00002884949,0.000006704967,0.000009677792,0.00003996694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002063769,0.0000343077,0.002528202,0.00005060673,0.00001340726,0.003487558,0.00002580382,0.0001075904,0.9907516,0.0001022074,0.00009622218,0.002596108],"study_design_scores_gemma":[0.0001596592,0.0007576328,0.1949056,0.00003718027,0.0001258575,0.05282906,0.00009294967,0.006497069,0.7263983,0.0005198438,0.01763609,0.00004076089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957108,0.0009875649,0.002461918,0.00006199913,0.00001819078,0.00001592349,0.0002826152,0.0000407941,0.0004202366],"genre_scores_gemma":[0.9955302,0.0002971752,0.002423441,0.00007476796,0.00001268751,0.000009326563,0.000796449,0.000008277672,0.0008476632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003976132,"threshold_uncertainty_score":0.001873016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251201467691361,"score_gpt":0.2857662405277601,"score_spread":0.260646093758624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}