{"id":"W2080825601","doi":"10.1091/mbc.e12-02-0128","title":"Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia","year":2012,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Mutant; Biology; Connexin; Gap junction; Mutation; Helix (gastropod); Wild type; Biophysics; Cell biology; Gene; Genetics; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345028,0.0004118349,0.0001541428,0.0001837702,0.0002280859,0.000131941,0.000160659,0.00034515,0.0003919114],"category_scores_gemma":[0.0002025006,0.0001647887,0.0002224041,0.000117776,0.0002724563,0.0001405832,0.0001517147,0.0002958883,0.0001453166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003360485,"about_ca_system_score_gemma":0.0001860618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001691866,"about_ca_topic_score_gemma":0.001479288,"domain_scores_codex":[0.9999231,0.00001934972,0.00001069074,0.00001421502,0.00001898004,0.00001362302],"domain_scores_gemma":[0.9998749,0.00002459485,0.00004360408,0.0000102244,0.00001303788,0.00003358897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005466588,0.0000225411,0.0002228005,0.0000147382,0.000004125588,0.0001334405,0.00002637693,0.00008164783,0.999149,0.00006053466,0.00000774311,0.000222331],"study_design_scores_gemma":[0.00003821071,0.0003111228,0.01464524,0.000006209274,0.00004203652,0.001172745,0.00009324582,0.00201234,0.9804425,0.00009310569,0.001133673,0.000009571144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993318,0.0001011316,0.0003216451,0.0000144195,0.00000325981,0.000003453694,0.00005634191,0.000005024713,0.0001629239],"genre_scores_gemma":[0.9982353,0.0001795818,0.0008177857,0.00001812909,0.000002555304,0.00000939149,0.0002458295,0.00001190661,0.000479551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691866,"threshold_uncertainty_score":0.003364086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285236383415342,"score_gpt":0.2656743262508986,"score_spread":0.2528219624167451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}