{"id":"W2080832356","doi":"10.1002/anie.200802919","title":"Solid‐Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Lantibiotics; Lanthionine; Thioether; Peptide; Chemistry; Combinatorial chemistry; Stereochemistry; Bacteriocin; Bacteria; Biochemistry; Biology; Organic chemistry; Antimicrobial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004794855,0.0001168062,0.0001898905,0.00007723413,0.00008045696,0.000008920651,0.0000979353,0.0001186933,0.0006811093],"category_scores_gemma":[0.001704179,0.00007193713,0.00009368142,0.0001293732,0.000186881,0.00009859129,0.00004859587,0.0001448391,0.000006433846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000835492,"about_ca_system_score_gemma":0.00009254153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005281712,"about_ca_topic_score_gemma":0.000006816457,"domain_scores_codex":[0.99887,0.00005811963,0.0002519633,0.0002382232,0.0004659989,0.0001157663],"domain_scores_gemma":[0.999,0.0001443254,0.0001717824,0.0001590092,0.0004787834,0.00004607113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001059289,0.0001144288,0.005393902,0.00003067309,0.0001008947,0.000003535601,0.0000633161,8.574177e-7,0.9863452,0.00002297411,0.006917181,0.0009010809],"study_design_scores_gemma":[0.0004059647,0.00003311348,0.1169527,0.000123121,0.0001559622,0.0001613118,0.00003926694,0.0000825933,0.8801016,0.00008265592,0.001786751,0.0000750534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914151,0.000134226,0.00001714215,0.005011363,0.000478827,0.0002539894,0.00005683106,0.00002364088,0.002608826],"genre_scores_gemma":[0.9980636,0.0003070758,0.0001595708,0.0003190146,0.0006659143,0.000002957211,0.00009411348,0.000008705227,0.0003790262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1115588,"threshold_uncertainty_score":0.7457669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0536426232474386,"score_gpt":0.3135254638544167,"score_spread":0.2598828406069781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}