{"id":"W2080867987","doi":"10.1523/jneurosci.2584-06.2007","title":"Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression; National Institutes of Health; National Institute of Mental Health; Medical Research Council; Giannini Foundation of Agricultural Economics; Wellcome Trust; Ellison Medical Foundation","keywords":"Endocrinology; Internal medicine; Serotonin; Hypothalamus; Agonist; 5-HT receptor; Receptor; Corticotropin-releasing hormone; Stimulation; In situ hybridization; Downregulation and upregulation; Chemistry; Corticosterone; Biology; Hormone; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001497564,0.0002106586,0.0002365874,0.0002456139,0.0005537929,0.0001727743,0.0009628937,0.0000773526,0.00007059977],"category_scores_gemma":[0.001087266,0.000141078,0.0001656263,0.0009341243,0.0004144577,0.001164328,0.0001174115,0.0004992469,0.00003796863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008578656,"about_ca_system_score_gemma":0.0001042534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007492264,"about_ca_topic_score_gemma":0.000003382744,"domain_scores_codex":[0.9971114,0.0002086236,0.0006773168,0.0003774236,0.001158584,0.0004666575],"domain_scores_gemma":[0.9978538,0.0006794672,0.0007449577,0.0003418565,0.0001758185,0.0002040788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001160826,0.0001023087,0.004577235,0.000005001802,0.000001149363,0.00004278303,0.0001708806,0.002115145,0.9893649,0.0002237226,0.0001892304,0.003091561],"study_design_scores_gemma":[0.0003384257,0.000321041,0.2116114,0.00002815047,0.000006823468,0.0003909315,0.00002921623,0.002957473,0.7771105,0.0004490141,0.006617865,0.0001392154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884592,0.00002102125,0.007986224,0.001658052,0.001087985,0.0003192404,0.000003474477,0.00003225944,0.0004325875],"genre_scores_gemma":[0.9970904,0.0000502911,0.0006637189,0.001500808,0.0002886463,0.000002040772,2.673151e-7,0.00001782383,0.0003859919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2122544,"threshold_uncertainty_score":0.5752994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03130247747209652,"score_gpt":0.2809862103230612,"score_spread":0.2496837328509647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}