{"id":"W2080870901","doi":"10.1016/j.ddtec.2012.09.002","title":"Histone H2B ubiquitination: signaling not scrapping","year":2012,"lang":"en","type":"review","venue":"Drug Discovery Today Technologies","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Agence Nationale de la Recherche; CNIB","keywords":"Histone H2B; Ubiquitin; Histone; Cell biology; Chemistry; Biology; Biochemistry; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005286583,0.0007405063,0.001162904,0.0003072561,0.0002394803,0.0001510581,0.001441675,0.001022205,0.00003306575],"category_scores_gemma":[0.0003733316,0.0006414111,0.0006417781,0.000347089,0.0003309277,0.00003358274,0.001342899,0.0006270405,0.0001006146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001160582,"about_ca_system_score_gemma":0.0002532272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007953478,"about_ca_topic_score_gemma":0.00000491737,"domain_scores_codex":[0.9972599,0.0001469848,0.0006968811,0.0008726942,0.000298342,0.0007252615],"domain_scores_gemma":[0.9977277,0.00006826827,0.0005639219,0.001500783,0.00007737729,0.00006197865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001384193,0.00009254487,0.000006690323,0.005458716,0.0002376592,0.00001246806,0.00003958015,0.000001882574,0.003386911,0.00213308,0.002856053,0.9857606],"study_design_scores_gemma":[0.0001227516,0.00005677981,4.416544e-7,0.002289337,0.0002853975,0.00004388905,0.0002014779,6.071757e-7,0.05290227,0.0002448873,0.943063,0.0007892075],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003433682,0.9946721,0.0004097145,0.0002034354,0.0004997804,0.000807031,0.0002220901,0.0004709796,0.002371465],"genre_scores_gemma":[0.005259359,0.9884419,0.0009393214,0.00008126515,0.000480036,0.000494906,0.0008761293,0.0001205767,0.003306453],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9849713,"threshold_uncertainty_score":0.9996037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04158342864300298,"score_gpt":0.3094269153860554,"score_spread":0.2678434867430524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}