{"id":"W2080874788","doi":"10.1371/journal.pone.0011291","title":"The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Guanine nucleotide exchange factor; SH3 domain; GTPase; Nucleotide; Allosteric regulation; Chemistry; Small GTPase; Biophysics; Biology; Biochemistry; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137654,0.0002401865,0.0002249684,0.000122483,0.0002149715,0.0003060972,0.0004956365,0.0001953662,0.000951227],"category_scores_gemma":[0.0001571015,0.0001352965,0.0001788916,0.0001900674,0.0003269338,0.0002026267,0.0003037494,0.000477835,0.0003415149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001050277,"about_ca_system_score_gemma":0.0004539599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001987455,"about_ca_topic_score_gemma":0.002420937,"domain_scores_codex":[0.999837,0.00002507062,0.00001562921,0.00004060401,0.00005195784,0.0000297343],"domain_scores_gemma":[0.9998634,0.00002661862,0.00003469945,0.00002694385,0.000009897135,0.00003850579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001649001,0.00005256089,0.0003645677,0.00002510661,0.000007843571,0.00003583599,0.00001418797,0.0002433378,0.9976675,0.0004894264,0.00003631053,0.0008982861],"study_design_scores_gemma":[0.00001738771,0.0001385509,0.002229563,0.00000509048,0.00001104503,0.0001381139,0.00001879174,0.001757461,0.993347,0.0001188585,0.002213468,0.000004716831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967553,0.0002825283,0.001984025,0.00003067639,0.000005665434,0.000009715472,0.0002142745,0.00002897247,0.0006888582],"genre_scores_gemma":[0.995113,0.00008776506,0.002751893,0.00001470971,0.000002206333,0.00001472195,0.001034211,0.00001307797,0.0009684555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987455,"threshold_uncertainty_score":0.007620335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02650207402955174,"score_gpt":0.2310362052452971,"score_spread":0.2045341312157453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}