{"id":"W2080924817","doi":"10.1158/1078-0432.ccr-07-0484","title":"Sorafenib Inhibits the Imatinib-Resistant <i>KIT</i> <i>T670I</i> Gatekeeper Mutation in Gastrointestinal Stromal Tumor","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Sorafenib; Nilotinib; Imatinib; Dasatinib; Cancer research; Imatinib mesylate; Tyrosine kinase; Proto-Oncogene Proteins c-kit; Tyrosine-kinase inhibitor; Sunitinib; PDGFRA; Medicine; Stromal cell; Pharmacology; Biology; GiST; Internal medicine; Cancer; Stem cell factor; Stem cell; Progenitor cell; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008726284,0.0002693286,0.0002623959,0.0001266775,0.0001148962,0.0001626708,0.0001136549,0.0001120211,0.0008660475],"category_scores_gemma":[0.00007813398,0.00006611964,0.000185034,0.0001022839,0.00009528817,0.00006789659,0.00008136354,0.0002663816,0.0002463303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083999,"about_ca_system_score_gemma":0.0001767488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006892078,"about_ca_topic_score_gemma":0.001667556,"domain_scores_codex":[0.9999348,0.00000997749,0.000006645756,0.000007419973,0.00001918525,0.00002189145],"domain_scores_gemma":[0.9999591,0.000006029839,0.00001233649,0.000003604061,0.000005813557,0.00001309722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002643733,0.0001087152,0.001131813,0.00004549369,0.00001084368,0.0001254438,0.000008895233,0.0001864213,0.993436,0.0000418508,0.000112006,0.004528233],"study_design_scores_gemma":[0.0001852973,0.003046447,0.01704665,0.000007751713,0.00005402464,0.002095128,0.00002167075,0.001931507,0.9726265,0.00003231187,0.002947012,0.000005672665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978741,0.0006999029,0.0004140601,0.00003956486,0.000008980814,0.00002363193,0.0001203405,0.00003208286,0.0007873728],"genre_scores_gemma":[0.9986057,0.0003753096,0.0003875612,0.00001899795,0.000004312792,0.0000117173,0.0002331762,0.000006628952,0.0003567174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008660475,"threshold_uncertainty_score":0.002897263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1724011015825633,"score_gpt":0.5144914392089194,"score_spread":0.3420903376263561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}