{"id":"W2080997258","doi":"10.1074/jbc.m311435200","title":"Identification of Proline Residues in the Core Cytoplasmic and Transmembrane Regions of Multidrug Resistance Protein 1 (MRP1/ABCC1) Important for Transport Function, Substrate Specificity, and Nucleotide Interactions","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Mutant; Transmembrane domain; Transport protein; ABCC1; ATP-binding cassette transporter; Transmembrane protein; Organic anion-transporting polypeptide; Cyclic nucleotide-binding domain; Chemistry; Transporter; Biochemistry; Biophysics; Nucleotide; Membrane transport protein; Biology; Amino acid; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168209,0.0002552579,0.0001554797,0.0001075795,0.0001146439,0.0001963088,0.0001525843,0.0002486119,0.0004053086],"category_scores_gemma":[0.0001600889,0.0001202561,0.0002444208,0.0001551718,0.0001590342,0.000120634,0.0001436741,0.0003039788,0.0002588905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765424,"about_ca_system_score_gemma":0.0001340743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004471253,"about_ca_topic_score_gemma":0.0004804234,"domain_scores_codex":[0.99992,0.00001975725,0.0000116603,0.00001663808,0.00001868858,0.00001321577],"domain_scores_gemma":[0.999799,0.00003619153,0.00009637132,0.00001619839,0.00001708804,0.00003517817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001852816,0.00001237346,0.000859376,0.0000348747,0.00000517594,0.0002024154,0.00001649282,0.0001050259,0.9975381,0.00005002072,0.00001375641,0.00097704],"study_design_scores_gemma":[0.00004832081,0.0005719149,0.03425064,0.00001506004,0.00005859126,0.003182409,0.00008433416,0.002106653,0.9563353,0.00008686571,0.003244975,0.00001487453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976465,0.0003895986,0.001422549,0.00002734855,0.000007631509,0.00001637916,0.0002524227,0.00001165323,0.0002258434],"genre_scores_gemma":[0.9953257,0.0004025955,0.003269387,0.00003003733,0.000006426203,0.000012872,0.0005625239,0.00000906168,0.0003814097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004471253,"threshold_uncertainty_score":0.001355886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775581309465202,"score_gpt":0.2659552417003744,"score_spread":0.2381994286057224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}