{"id":"W2081011802","doi":"10.1158/1538-7445.am2011-1644","title":"Abstract 1644: siRNA targeting of cell cycle kinase Wee1 inhibits hepatocullar carconima growth <i>in vitro</i> and <i>in vivo</i>","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Wee1; Cell cycle; Cancer research; Gene silencing; Biology; Small interfering RNA; Cell cycle checkpoint; Cell growth; Gene knockdown; Kinase; Cyclin-dependent kinase 1; Apoptosis; Chemistry; Molecular biology; Cell biology; Cell culture; Transfection; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378893,0.0005431476,0.0003246082,0.0003576925,0.0001379712,0.0001727021,0.0001764368,0.0002319846,0.002395554],"category_scores_gemma":[0.00007220482,0.00009797207,0.0002036631,0.0001819388,0.0001959322,0.0001563503,0.0001125807,0.0004594614,0.0005648392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265447,"about_ca_system_score_gemma":0.0003086698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001073146,"about_ca_topic_score_gemma":0.001063152,"domain_scores_codex":[0.9999003,0.00001517701,0.00001125186,0.00001531839,0.0000271832,0.00003080701],"domain_scores_gemma":[0.9999474,0.000007825861,0.00001139697,0.000005499494,0.00001091238,0.00001680601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003119795,0.0001096779,0.00006911071,0.00006629145,0.000005881451,0.00002809637,0.000007505657,0.00005411313,0.9975833,0.00005665245,0.0002005273,0.001507051],"study_design_scores_gemma":[0.00004355986,0.0008142622,0.001318531,0.000003247766,0.00001513816,0.00007717927,0.000009117433,0.0004941871,0.995708,0.00001366151,0.001500397,0.000002547976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868361,0.002970024,0.003250262,0.0002244973,0.0001203345,0.0001287795,0.001121229,0.0003996586,0.004949135],"genre_scores_gemma":[0.9854995,0.001366621,0.002450482,0.0001110765,0.00002985346,0.0001911488,0.002126938,0.00005629006,0.008168207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002395554,"threshold_uncertainty_score":0.008013904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0343672369633217,"score_gpt":0.3059567851538829,"score_spread":0.2715895481905611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}