{"id":"W2081013305","doi":"10.1128/jvi.75.19.9378-9392.2001","title":"The Pathogenicity of Human Immunodeficiency Virus (HIV) Type 1 Nef in CD4C/HIV Transgenic Mice Is Abolished by Mutation of Its SH3-Binding Domain, and Disease Development Is Delayed in the Absence of Hck","year":2001,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Medical Research Council Canada","keywords":"Biology; Effector; Genetically modified mouse; Virology; Transgene; Virus; Mutation; SH3 domain; Pathogenesis; Immunology; Genetics; Gene; Receptor; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008411089,0.0001139012,0.0003121517,0.0001605519,0.0001118367,0.000004558886,0.0002930496,0.0001093425,0.00008884643],"category_scores_gemma":[0.00008407726,0.00007076706,0.00007241394,0.0002247123,0.0002674002,0.00007140136,0.00003204836,0.0002862579,0.000008772592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003752026,"about_ca_system_score_gemma":0.0001774706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006545828,"about_ca_topic_score_gemma":0.000108618,"domain_scores_codex":[0.9983692,0.0004152981,0.0007235177,0.0001284633,0.0000968353,0.0002667067],"domain_scores_gemma":[0.9990643,0.0002418892,0.0004067695,0.0001352775,0.0001219004,0.00002982561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001990464,0.0005729979,0.01828407,0.00002007893,0.0001491645,0.00003192151,0.006590726,0.00001077219,0.9707797,0.00006045757,0.0002359372,0.001273709],"study_design_scores_gemma":[0.01008114,0.003023006,0.726574,0.0001449329,0.0001441968,0.0003645941,0.003156778,0.00002193737,0.2510652,0.0009855849,0.0041747,0.0002638846],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863612,0.01275667,0.00004875608,0.0004848648,0.00005333123,0.0001858267,0.00007262985,0.000001125192,0.00003558548],"genre_scores_gemma":[0.9974599,0.002349129,0.00003975131,0.00007316231,0.000004504453,0.00000547987,0.00001754368,0.000005394266,0.00004515737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7197145,"threshold_uncertainty_score":0.2885797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379609437332129,"score_gpt":0.2756720920965649,"score_spread":0.2618759977232436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}