{"id":"W2081013305","doi":"10.1128/jvi.75.19.9378-9392.2001","title":"The Pathogenicity of Human Immunodeficiency Virus (HIV) Type 1 Nef in CD4C/HIV Transgenic Mice Is Abolished by Mutation of Its SH3-Binding Domain, and Disease Development Is Delayed in the Absence of Hck","year":2001,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Medical Research Council Canada","keywords":"Biology; Effector; Genetically modified mouse; Virology; Transgene; Virus; Mutation; SH3 domain; Pathogenesis; Immunology; Genetics; Gene; Receptor; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003213759,0.00103407,0.0003989215,0.0009795588,0.000369484,0.000375952,0.0004555888,0.0009462133,0.002888467],"category_scores_gemma":[0.0001944451,0.0004412613,0.0003261306,0.000250068,0.000727306,0.0003792285,0.0003275284,0.001480254,0.0008013556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005149642,"about_ca_system_score_gemma":0.000315222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008200837,"about_ca_topic_score_gemma":0.001313865,"domain_scores_codex":[0.9996699,0.00004927316,0.00003518178,0.00007458701,0.00007859176,0.0000925519],"domain_scores_gemma":[0.9994878,0.00007002612,0.0001477513,0.00004366979,0.00002942088,0.0002213184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00022594,0.00008419942,0.000225967,0.00002857071,0.000006069432,0.0001600166,0.00002171931,0.0000392732,0.9982694,0.0001834664,0.00005191775,0.0007032857],"study_design_scores_gemma":[0.0002316895,0.001034057,0.01147216,0.00003326497,0.00004269739,0.001718801,0.00006941285,0.002246602,0.9801356,0.0002479483,0.002750603,0.00001731256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941755,0.0007330509,0.001994943,0.0001663581,0.00004020127,0.00005999948,0.0006005103,0.0002866595,0.001942833],"genre_scores_gemma":[0.9891349,0.000716576,0.00336714,0.0001221882,0.00003097573,0.0001238497,0.0008791428,0.0001207563,0.005504369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002888467,"threshold_uncertainty_score":0.009662926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379609437332129,"score_gpt":0.2756720920965649,"score_spread":0.2618759977232436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}