{"id":"W2081029482","doi":"10.4161/cc.4.10.2061","title":"Low Concentrations of Taxol Cause Mitotic Delay Followed by Premature Dissociation of p55CDC from Mad2 and BubR1 and Abrogation of the Spindle checkpoint, Leading to Aneuploidy","year":2005,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Cancer Institute; U.S. Public Health Service; U.S. Department of Defense","keywords":"Mad2; Spindle checkpoint; Mitosis; Biology; Aneuploidy; Mitotic exit; G2-M DNA damage checkpoint; Cell biology; Metaphase; Cell cycle checkpoint; Kinetochore; Chromosome segregation; Cell cycle; Spindle apparatus; Cancer research; Genetics; Chromosome; Anaphase; Apoptosis; Cell division; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000473328,0.00007106498,0.0001121644,0.00001195612,0.00003351255,0.000005658063,0.00006318102,0.00009796832,0.000004320248],"category_scores_gemma":[0.00003068809,0.00006227717,0.00003740366,0.00004743175,0.00005135998,0.000006257319,0.0000402332,0.00003908436,3.968509e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009690063,"about_ca_system_score_gemma":0.00001911593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004447795,"about_ca_topic_score_gemma":0.0001794754,"domain_scores_codex":[0.9995123,0.00002484152,0.0001816238,0.0001377564,0.00006256202,0.00008087986],"domain_scores_gemma":[0.9996092,0.00001186652,0.0001507359,0.0001486635,0.00004765216,0.00003186626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001406234,0.00005943928,0.007166069,0.00003686677,0.00002084854,4.521926e-8,0.0003941124,0.0001484021,0.9915738,0.000007431115,0.0004227454,0.0001561896],"study_design_scores_gemma":[0.0003498629,0.0000579939,0.006327483,0.00003096483,0.00004298456,5.805103e-7,0.0001145029,0.0003795438,0.9923664,0.00001175307,0.0002561918,0.00006176346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982697,0.0006093908,0.0005728153,0.00008931133,0.00003212408,0.0002229752,0.0001171606,0.000002033126,0.00008449946],"genre_scores_gemma":[0.9990276,0.0001280583,0.0004751676,0.0000417986,0.00003061067,0.000004729993,0.00008987426,0.000008042282,0.0001941707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008385862,"threshold_uncertainty_score":0.2539589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003376814030148074,"score_gpt":0.2083335981210378,"score_spread":0.2049567840908897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}