{"id":"W2081029482","doi":"10.4161/cc.4.10.2061","title":"Low Concentrations of Taxol Cause Mitotic Delay Followed by Premature Dissociation of p55CDC from Mad2 and BubR1 and Abrogation of the Spindle checkpoint, Leading to Aneuploidy","year":2005,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Cancer Institute; U.S. Public Health Service; U.S. Department of Defense","keywords":"Mad2; Spindle checkpoint; Mitosis; Biology; Aneuploidy; Mitotic exit; G2-M DNA damage checkpoint; Cell biology; Metaphase; Cell cycle checkpoint; Kinetochore; Chromosome segregation; Cell cycle; Spindle apparatus; Cancer research; Genetics; Chromosome; Anaphase; Apoptosis; Cell division; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004604385,0.0002813565,0.0002404115,0.0001748368,0.0001322551,0.0002660237,0.0001784124,0.0002259913,0.001495613],"category_scores_gemma":[0.00009888032,0.0000975521,0.0001224491,0.0001560856,0.0001901961,0.0001145299,0.0001020629,0.0006204025,0.0004033143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988799,"about_ca_system_score_gemma":0.0001915003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008895683,"about_ca_topic_score_gemma":0.001898816,"domain_scores_codex":[0.9999194,0.00001472699,0.000009454624,0.00001331931,0.00001989961,0.00002321256],"domain_scores_gemma":[0.9999074,0.00002390321,0.00002369007,0.0000121471,0.000008720268,0.00002412768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009455874,0.00003448609,0.0001027387,0.0000237587,0.000002980163,0.00004198704,0.000005555691,0.00003261919,0.998808,0.00007336069,0.00005914322,0.000720894],"study_design_scores_gemma":[0.00001164507,0.0001390398,0.0008401262,0.000001990637,0.000004890329,0.0001179064,0.000008329168,0.0001775047,0.9975393,0.00002641862,0.001131121,0.000001685695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923999,0.002260696,0.00234529,0.0002045876,0.00005704663,0.00003847036,0.0006103729,0.00009614651,0.001987533],"genre_scores_gemma":[0.9930558,0.001047923,0.00216579,0.00007443489,0.00001425053,0.00003178504,0.0006934275,0.00001622521,0.002900443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495613,"threshold_uncertainty_score":0.005003273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003376814030148074,"score_gpt":0.2083335981210378,"score_spread":0.2049567840908897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}