{"id":"W2081047047","doi":"10.1371/journal.pone.0119920","title":"Inherited Variation at MC1R and Histological Characteristics of Primary Melanoma","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Women's College Hospital","funders":"University of California, Irvine; University of North Carolina at Chapel Hill; Missouri Department of Health and Senior Services; Menzies Institute for Medical Research; University of Sydney; University of Tasmania; Michael Smith Health Research BC; National Institute of Environmental Health Sciences; Memorial Sloan-Kettering Cancer Center; Cancer Council NSW; Menzies Research Institute Tasmania; Cancer Care Ontario; University of Pennsylvania; National Cancer Institute; State of New Jersey Department of Health; University of Southern California","keywords":"Melanoma; Melanocortin 1 receptor; Medicine; Breslow Thickness; Nonsynonymous substitution; Vemurafenib; Cancer; Genotype; Eye color; Pathology; Dermatology; Phenotype; Internal medicine; Oncology; Biology; Genetics; Gene; Breast cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009332041,0.00006077506,0.0002344062,0.00005360878,0.00001848211,0.000003937672,0.00002129031,0.00005521927,0.0001006557],"category_scores_gemma":[0.0001378943,0.00005399274,0.00001605559,0.00005793114,0.0000329523,0.00001757054,0.00005302474,0.00005681155,0.00002621515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343493,"about_ca_system_score_gemma":0.00001877704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000150025,"about_ca_topic_score_gemma":0.000003113176,"domain_scores_codex":[0.9994211,0.00002280896,0.0001660577,0.0001150353,0.0001995474,0.00007546247],"domain_scores_gemma":[0.9995949,0.00002049104,0.00008077127,0.0001209119,0.00008789224,0.00009500581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003821781,0.00645043,0.1596823,0.001498419,0.001040928,0.0004413277,0.002043665,3.588488e-7,0.8024101,0.0008982005,0.003067255,0.01864526],"study_design_scores_gemma":[0.002770605,0.00195931,0.9772717,0.0001487956,0.0007274916,0.0002097218,0.00006088853,0.0007492399,0.007138893,0.0001219866,0.008645169,0.0001962143],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924482,0.0001009282,0.00008205422,0.0005262327,0.00004936701,0.0002272126,0.000004885085,0.00004957655,0.006511524],"genre_scores_gemma":[0.9943019,0.00004722279,0.001800806,0.000300203,0.00006844283,0.000008471573,0.00003535183,0.000007932333,0.003429685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8175894,"threshold_uncertainty_score":0.220176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06643190672724582,"score_gpt":0.2253211514573099,"score_spread":0.158889244730064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}