{"id":"W2081098836","doi":"10.1158/0008-5472.can-03-2031","title":"Accelerated Induction of Bladder Cancer in <b> <i>Patched</i> </b> Heterozygous Mutant Mice","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec; Occupational Cancer Research Centre","funders":"National Cancer Institute","keywords":"Carcinogenesis; Patched; Bladder cancer; Cancer; Mutant; Cancer research; Wild type; Tumor suppressor gene; Suppressor; Nitrosamine; Basal (medicine); Biology; Pathology; Gene; Internal medicine; Endocrinology; Medicine; Carcinogen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002811023,0.0007193684,0.0005113108,0.001036896,0.0002535395,0.000397312,0.0003326354,0.0006726278,0.003009976],"category_scores_gemma":[0.0002409117,0.0004727947,0.0005715763,0.0002809319,0.0004788004,0.0003061608,0.0004032062,0.001084685,0.0007944639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000328945,"about_ca_system_score_gemma":0.0002724854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009855664,"about_ca_topic_score_gemma":0.001116861,"domain_scores_codex":[0.9995545,0.00007445915,0.00005009259,0.0001119145,0.00009926756,0.0001098893],"domain_scores_gemma":[0.9992663,0.00008199821,0.0002395986,0.00008579221,0.0000469307,0.0002794448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001034045,0.00001848659,0.00009594215,0.00001323661,0.000003937727,0.0000492549,0.000009433636,0.00002806497,0.9993186,0.00008056658,0.00001683422,0.0002622601],"study_design_scores_gemma":[0.00003936706,0.000547712,0.004697244,0.000009974715,0.00002524422,0.0005485997,0.00002285405,0.0006219177,0.9923599,0.00008455438,0.001031722,0.0000108872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920649,0.0004998127,0.004690059,0.0000965893,0.00005162327,0.00005408247,0.0007928252,0.0004629199,0.001287041],"genre_scores_gemma":[0.9848807,0.000640261,0.005325485,0.00007207505,0.00002490377,0.00009423139,0.0008269212,0.000304223,0.007831302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003009976,"threshold_uncertainty_score":0.01006937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1015992443227833,"score_gpt":0.4062110777282268,"score_spread":0.3046118334054436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}