{"id":"W2081141707","doi":"10.1186/1471-2407-13-605","title":"Molecular Signaling Pathways Mediating Osteoclastogenesis Induced by Prostate Cancer Cells","year":2013,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Shriners Hospitals for Children - Canada","funders":"Canadian Institutes of Health Research; University of Toronto; McGill University","keywords":"RANKL; Osteoclast; Prostate cancer; Cancer research; Bone resorption; NFAT; Bone metastasis; Osteoprotegerin; Prostate; Signal transduction; Medicine; Internal medicine; Cancer; Chemistry; Activator (genetics); Endocrinology; Receptor; Cell biology; Biology; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006839092,0.0002148771,0.0001840813,0.00002921303,0.00008305151,0.00005877652,0.0001592618,0.0001248966,0.0002317026],"category_scores_gemma":[0.00003291167,0.0001998256,0.0001072299,0.0001067981,0.00003875851,0.00001072265,0.00009732341,0.0000645086,0.00002577985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002205556,"about_ca_system_score_gemma":0.0002703411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132254,"about_ca_topic_score_gemma":0.0001031051,"domain_scores_codex":[0.9987349,0.00006381994,0.000221377,0.0004224225,0.0001896098,0.0003678627],"domain_scores_gemma":[0.9992975,0.00001176389,0.0001200466,0.0002650813,0.0001247685,0.0001808499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002594616,0.00002795217,0.00373185,0.00004033124,0.00003218959,8.358006e-7,0.00005997809,0.0004228085,0.9873059,0.000004955782,0.003419296,0.004927937],"study_design_scores_gemma":[0.0005042823,0.00003505726,0.001340425,0.00002082879,0.00004702621,4.175303e-7,0.0001033433,0.00006852424,0.9928298,0.00002277825,0.004735572,0.0002919341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830436,0.01549921,0.0002032942,0.00006904059,0.0003446831,0.0003592799,0.0002540186,0.00002502576,0.0002018331],"genre_scores_gemma":[0.9967884,0.000601036,0.0003076663,0.0008002869,0.0003569114,0.0007063316,0.00009313733,0.00004996233,0.0002962976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01489817,"threshold_uncertainty_score":0.814865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197799842713603,"score_gpt":0.2364270041553315,"score_spread":0.2244490057281955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}