{"id":"W2081167504","doi":"10.1158/1538-7445.am10-4467","title":"Abstract 4467: Differential response of ERa-targeted therapy in breast and ovarian cancer cells by 17b-estradiol-linked platinum(II) hybrid (E2-Pt(II)), VP-128","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Cisplatin; Ovarian cancer; Breast cancer; Cancer research; Cancer cell; In vivo; XIAP; Apoptosis; In vitro; Chemistry; Western blot; Protein kinase B; Cancer; Molecular biology; Internal medicine; Biology; Medicine; Caspase; Chemotherapy; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007305233,0.0002208676,0.0003425097,0.0001411566,0.00006448678,0.0001867283,0.0001252333,0.0002922063,0.002557543],"category_scores_gemma":[0.0000867492,0.00012611,0.0001606479,0.000182429,0.00009748245,0.0001570759,0.000140684,0.000329191,0.0004368788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001127619,"about_ca_system_score_gemma":0.00009896212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003437164,"about_ca_topic_score_gemma":0.0001919295,"domain_scores_codex":[0.9999068,0.00001477512,0.00001094218,0.00001983671,0.00002901116,0.00001872164],"domain_scores_gemma":[0.9999691,0.00000894977,0.000005278627,0.000004591043,0.000004934897,0.000007163641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002676355,0.00004495748,0.0001165766,0.00006154113,0.000006200916,0.00007165361,0.0000193017,0.000109734,0.9969632,0.00005866362,0.00008363146,0.002196857],"study_design_scores_gemma":[0.0000294201,0.000606591,0.001583363,0.000003393049,0.000008181168,0.0001673,0.00001302901,0.0005742896,0.9954413,0.00001639254,0.001554265,0.000002429454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946147,0.001934217,0.0009699888,0.00006801375,0.00005267658,0.00003354195,0.0003891457,0.00005391641,0.001883872],"genre_scores_gemma":[0.9927788,0.000973164,0.001010145,0.00004071077,0.000009340832,0.00004753728,0.0006181652,0.0000184751,0.00450355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002557543,"threshold_uncertainty_score":0.00855583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06895469401684566,"score_gpt":0.3523584617946381,"score_spread":0.2834037677777925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}