{"id":"W2081167504","doi":"10.1158/1538-7445.am10-4467","title":"Abstract 4467: Differential response of ERa-targeted therapy in breast and ovarian cancer cells by 17b-estradiol-linked platinum(II) hybrid (E2-Pt(II)), VP-128","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Cisplatin; Ovarian cancer; Breast cancer; Cancer research; Cancer cell; In vivo; XIAP; Apoptosis; In vitro; Chemistry; Western blot; Protein kinase B; Cancer; Molecular biology; Internal medicine; Biology; Medicine; Caspase; Chemotherapy; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001555899,0.000278064,0.0006338042,0.000344784,0.0002875181,0.00005571586,0.0003065842,0.000168557,0.004559891],"category_scores_gemma":[0.0001455496,0.0002079814,0.0001035043,0.0003336451,0.0005267825,0.0001195405,0.000140438,0.001314927,0.000007107621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188875,"about_ca_system_score_gemma":0.0007078541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00659387,"about_ca_topic_score_gemma":0.0004604334,"domain_scores_codex":[0.9970425,0.000378724,0.0005294895,0.0005467244,0.0008194611,0.0006831179],"domain_scores_gemma":[0.9983572,0.0003865789,0.0001180171,0.0005420944,0.0002979235,0.0002981698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01009493,0.0002669906,0.006094264,0.0001364178,0.0001026101,0.00002407522,0.0007899312,0.000001968613,0.9612402,0.00001796194,0.004023309,0.01720738],"study_design_scores_gemma":[0.00265349,0.0005176614,0.3094693,0.0002682027,0.00001735641,0.00002618923,0.00007861279,0.0001170188,0.680685,0.0000667007,0.005876331,0.0002241039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922529,0.003106587,0.000001934321,0.002732856,0.0002944897,0.0007726601,0.000482488,0.00002686303,0.0003291896],"genre_scores_gemma":[0.9958777,0.001934212,0.00008351312,0.00007863987,0.0003260696,0.0001874334,0.00002985225,0.00005872479,0.001423808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3033751,"threshold_uncertainty_score":0.9968002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06895469401684566,"score_gpt":0.3523584617946381,"score_spread":0.2834037677777925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}