{"id":"W2081173366","doi":"10.1016/j.tibs.2008.04.004","title":"Pre-mRNA splicing: a complex picture in higher definition","year":2008,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polypyrimidine tract; RNA splicing; Spliceosome; Intron; Exon; Splicing factor; splice; Genetics; Exonic splicing enhancer; Computational biology; Biology; Alternative splicing; Precursor mRNA; Splice site mutation; Cell biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002510637,0.0003302027,0.0006534564,0.0003802135,0.00008270489,0.00004123825,0.0006805071,0.0004711424,0.0001280309],"category_scores_gemma":[0.00007350024,0.0002461866,0.0002352413,0.001172388,0.000463468,0.000005534892,0.0002288502,0.0003827396,0.00001129686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007058046,"about_ca_system_score_gemma":0.0001425072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007774584,"about_ca_topic_score_gemma":0.00006170705,"domain_scores_codex":[0.9976905,0.0001238415,0.0004683778,0.0007806789,0.000343131,0.0005934428],"domain_scores_gemma":[0.9993843,0.00004379703,0.000127971,0.0002965348,0.0000187947,0.0001286374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005289336,0.0003303677,0.000668305,0.001214833,0.00004751741,0.00006651717,0.00004761447,0.000007928882,0.0402935,0.000269094,0.01577733,0.9412241],"study_design_scores_gemma":[0.000466616,0.0002871426,0.0008740535,0.001991469,0.00002141575,0.00009120737,0.00001275893,0.00002906298,0.001168467,0.00009374641,0.9942697,0.0006943126],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02075715,0.9715917,0.000002810905,0.00008452814,0.00007678466,0.0001782694,0.00002489423,0.0000121795,0.007271661],"genre_scores_gemma":[0.009376652,0.9883157,0.0004626263,0.00007696696,0.0002146083,0.00006178515,0.0003888613,0.00001915254,0.001083624],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9784924,"threshold_uncertainty_score":0.999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.17378973028772,"score_gpt":0.4013830099817747,"score_spread":0.2275932796940547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}