{"id":"W2081173366","doi":"10.1016/j.tibs.2008.04.004","title":"Pre-mRNA splicing: a complex picture in higher definition","year":2008,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polypyrimidine tract; RNA splicing; Spliceosome; Intron; Exon; Splicing factor; splice; Genetics; Exonic splicing enhancer; Computational biology; Biology; Alternative splicing; Precursor mRNA; Splice site mutation; Cell biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267677,0.001121204,0.002261427,0.001263477,0.0003978625,0.001939422,0.001693889,0.002066658,0.001967981],"category_scores_gemma":[0.0009851576,0.0004265891,0.0003801156,0.002251299,0.002378632,0.004641405,0.001003463,0.003122179,0.002050719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000992518,"about_ca_system_score_gemma":0.001128256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003669493,"about_ca_topic_score_gemma":0.000518575,"domain_scores_codex":[0.9997229,0.00004272539,0.00004053059,0.00006853932,0.000101842,0.00002334601],"domain_scores_gemma":[0.9995289,0.0002602414,0.00004428184,0.00003105433,0.000100457,0.00003507732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001187646,0.00003850722,0.0001457358,0.007877883,0.0000517002,0.0004255286,0.0001702166,0.0005923498,0.007263926,0.05697843,0.02523417,0.9011028],"study_design_scores_gemma":[0.00001729335,0.00006561447,0.0004186456,0.001311493,0.00004675746,0.00185768,0.0001207329,0.000193169,0.001743751,0.0318507,0.9623407,0.00003360976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002774325,0.9938468,0.00209411,0.001298847,0.0009257831,0.000003750963,0.00001460276,0.00002663793,0.00151189],"genre_scores_gemma":[0.001327715,0.9944466,0.001513089,0.0008884176,0.0007636551,0.00001202987,0.00003809815,0.000006721004,0.001003697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002261427,"threshold_uncertainty_score":0.007201254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.17378973028772,"score_gpt":0.4013830099817747,"score_spread":0.2275932796940547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}