{"id":"W2081181781","doi":"10.1007/s10637-007-9103-2","title":"A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168)","year":2008,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Regional Cancer Foundation; Hamilton Regional Laboratory Medicine Program; Ottawa Hospital; Princess Margaret Cancer Centre; BC Cancer Agency; University Health Network; University of Toronto; Cancer Care Ontario; Queen's University","funders":"National Cancer Institute","keywords":"Medicine; Leukocytopenia; Internal medicine; Hepatocellular carcinoma; Gastroenterology; Phases of clinical research; Cancer; Liver function; Pharmacokinetics; Neutropenia; Toxicity; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005622382,0.0001532704,0.0004159747,0.0000644108,0.00007008913,0.000002603374,0.000180317,0.00004461555,0.000006500899],"category_scores_gemma":[0.000282118,0.0001139052,0.00005045497,0.0002198927,0.0002141355,0.00001047045,0.0001103659,0.0001116448,3.351845e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003476377,"about_ca_system_score_gemma":0.001826153,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.03979568,"about_ca_topic_score_gemma":0.04727831,"domain_scores_codex":[0.9978095,0.00034996,0.0009096758,0.0002781897,0.0005321106,0.0001205474],"domain_scores_gemma":[0.9988701,0.00007078372,0.0005420502,0.0001573442,0.0002648673,0.00009489859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005390649,0.005484859,0.9730406,0.00004130498,0.0003729787,0.000003017019,0.001403001,0.0008796272,0.01720921,0.00002642053,0.0007586209,0.0002413288],"study_design_scores_gemma":[0.05462679,0.00550305,0.9189701,0.00008529993,0.0003984641,0.000005729297,0.0006206341,0.001281773,0.01756517,0.0001178288,0.0004674502,0.0003576982],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983708,0.0001453237,0.00001021226,0.00005690656,0.0001098144,0.001161034,0.0001338041,0.00000117635,0.00001088451],"genre_scores_gemma":[0.9994573,0.00001499254,0.0001435938,0.0001570185,0.00005566273,0.00005105537,0.00006489747,0.00001134147,0.00004414401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05408772,"threshold_uncertainty_score":0.9701064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06080585527464875,"score_gpt":0.3347445557224106,"score_spread":0.2739387004477618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}