{"id":"W2081181781","doi":"10.1007/s10637-007-9103-2","title":"A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168)","year":2008,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Regional Cancer Foundation; Hamilton Regional Laboratory Medicine Program; Ottawa Hospital; Princess Margaret Cancer Centre; BC Cancer Agency; University Health Network; University of Toronto; Cancer Care Ontario; Queen's University","funders":"National Cancer Institute","keywords":"Medicine; Leukocytopenia; Internal medicine; Hepatocellular carcinoma; Gastroenterology; Phases of clinical research; Cancer; Liver function; Pharmacokinetics; Neutropenia; Toxicity; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262617,0.002029021,0.002966561,0.0006593852,0.000577265,0.0009939304,0.00091492,0.001608033,0.003154816],"category_scores_gemma":[0.001203059,0.0008347323,0.001407676,0.0007868287,0.001164445,0.001075626,0.0003276724,0.004375518,0.001146822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001380149,"about_ca_system_score_gemma":0.00222876,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005782236,"about_ca_topic_score_gemma":0.009931062,"domain_scores_codex":[0.9996351,0.0001685087,0.00001287973,0.00005468142,0.00004046377,0.00008833466],"domain_scores_gemma":[0.9991832,0.0001196331,0.0001148199,0.0000686718,0.00004674813,0.000466882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7036815,0.06838562,0.01238903,0.0008093162,0.00185561,0.0006014858,0.0004324637,0.005207717,0.06376314,0.0004856749,0.009530139,0.1328582],"study_design_scores_gemma":[0.5946732,0.3752063,0.01948383,0.00002986109,0.0005391782,0.0004830904,0.0001041779,0.001808698,0.0039824,0.000268003,0.003349978,0.00007114794],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901816,0.002845211,0.0006372107,0.000932641,0.0001622174,0.001402382,0.001799978,0.0001199487,0.001918834],"genre_scores_gemma":[0.9853909,0.00344615,0.001905595,0.001124376,0.0002199412,0.001634717,0.002965148,0.00007633486,0.003236838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9942178,"threshold_uncertainty_score":0.0114972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06080585527464875,"score_gpt":0.3347445557224106,"score_spread":0.2739387004477618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}