{"id":"W2081210628","doi":"10.1371/journal.pbio.1001666","title":"Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism","year":2013,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Medical Research Council; British Heart Foundation","keywords":"Biology; Hypoxia (environmental); Downregulation and upregulation; Glycolysis; Heart development; Endocrinology; Lipid metabolism; Fetus; Internal medicine; Mitochondrion; Cell biology; Regulation of gene expression; Embryonic stem cell; Metabolism; Oxygen; Biochemistry; Gene; Genetics; Medicine; Chemistry; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168894,0.0002256824,0.0002228092,0.0001383357,0.0001256293,0.0002739906,0.0002078861,0.0002111702,0.001512675],"category_scores_gemma":[0.0001396367,0.0001336839,0.0001430593,0.00007154062,0.0002715769,0.0001751604,0.0003671042,0.0003614098,0.0003596543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499076,"about_ca_system_score_gemma":0.0001844691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004272564,"about_ca_topic_score_gemma":0.0007276149,"domain_scores_codex":[0.9999,0.000009965236,0.000004793019,0.00003327036,0.00002139583,0.00003066735],"domain_scores_gemma":[0.9998543,0.00002512793,0.00004778941,0.00001213231,0.00001129677,0.00004926481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001240307,0.000005894124,0.0003713066,0.00002543692,0.000001906305,0.00004594056,0.00001131997,0.00005910591,0.9967655,0.0001564881,0.00004158323,0.002391461],"study_design_scores_gemma":[0.00001812907,0.0001982495,0.056292,0.00002667656,0.00001848593,0.0003695698,0.0000788128,0.001338359,0.9366201,0.0003570415,0.004668872,0.00001377975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870256,0.004210198,0.004639756,0.0002071414,0.00005353947,0.00001004115,0.0004370431,0.0001730621,0.003243554],"genre_scores_gemma":[0.9938346,0.0013729,0.001414123,0.00009234263,0.00001586598,0.00001708292,0.0003278067,0.00004337966,0.002881893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512675,"threshold_uncertainty_score":0.005060434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006626253049815971,"score_gpt":0.2128011253237194,"score_spread":0.2061748722739034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}