{"id":"W2081213990","doi":"10.1016/j.taap.2004.10.012","title":"Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense","year":2004,"lang":"en","type":"review","venue":"Toxicology and Applied Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1414,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Abcg2; Multidrug resistance-associated protein 2; ATP-binding cassette transporter; P-glycoprotein; ABCC1; Multidrug Resistance-Associated Proteins; Efflux; Transporter; Biology; Drug metabolism; Solute carrier family; Pharmacology; Biochemistry; Multiple drug resistance; Chemistry; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005742766,0.001058681,0.001823154,0.001876711,0.000300813,0.001178026,0.001051336,0.001209025,0.003234991],"category_scores_gemma":[0.0005022209,0.000307238,0.0003364758,0.003226331,0.000525213,0.001588605,0.0005389215,0.001727281,0.00336236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007698514,"about_ca_system_score_gemma":0.00115591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285758,"about_ca_topic_score_gemma":0.002789368,"domain_scores_codex":[0.999831,0.00002507104,0.00002119469,0.00003124719,0.00007573862,0.00001578345],"domain_scores_gemma":[0.9996548,0.0001044877,0.00005854358,0.0000115841,0.0001307379,0.00003994786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009940691,0.00009105237,0.0001981384,0.008721773,0.00007822565,0.0002871219,0.00004931889,0.0003623266,0.004315736,0.002358698,0.03119901,0.9522392],"study_design_scores_gemma":[0.00002242889,0.00007887848,0.0007730653,0.0009942512,0.00008701111,0.001426771,0.00004246208,0.00009497554,0.0008325863,0.001231634,0.9943998,0.00001614913],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001388452,0.9982686,0.0002879048,0.0002545002,0.0001590001,0.000005263945,0.00001720131,0.0000099412,0.0008587912],"genre_scores_gemma":[0.0006062211,0.9974506,0.0004499696,0.0001690315,0.0001486054,0.00000626437,0.00003906594,0.000001350867,0.001128818],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003234991,"threshold_uncertainty_score":0.01082212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608974051230079,"score_gpt":0.3154854751925383,"score_spread":0.2993957346802376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}