{"id":"W2081220190","doi":"10.1186/1471-2199-11-101","title":"The CTCF insulator protein forms an unusual DNA structure","year":2010,"lang":"en","type":"article","venue":"BMC Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"CTCF; Biology; Zinc finger; Insulator (electricity); DNA; Genetics; HMG-box; DNA-binding domain; Gene; Protein–DNA interaction; Molecular biology; Cell biology; DNA-binding protein; Enhancer; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930948,0.0002341238,0.0001505841,0.00002990164,0.0002199918,0.00005439212,0.0005672126,0.0004437528,0.00001407355],"category_scores_gemma":[0.0001243794,0.0001629714,0.0001095395,0.00007100114,0.000236179,0.000003110256,0.0002155716,0.0002445437,0.000007877277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000848329,"about_ca_system_score_gemma":0.0001531989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001309708,"about_ca_topic_score_gemma":0.0007566377,"domain_scores_codex":[0.9987035,0.00009589655,0.0002492984,0.000455758,0.00008065507,0.0004148297],"domain_scores_gemma":[0.9988092,0.000009604873,0.0001206178,0.0008478871,0.00008528743,0.0001274417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004127617,0.00002601804,0.001105744,0.000005928542,0.00003057631,0.000001732946,0.00001224334,0.00001627743,0.975787,0.02124032,0.00002312091,0.001709782],"study_design_scores_gemma":[0.0006845801,0.0006013685,0.003173657,0.000002761709,0.00001660615,0.00006754847,0.00005952225,0.0006208182,0.952552,0.01346246,0.02833166,0.0004270018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945067,0.0001610245,0.004186692,0.00007986088,0.0002767573,0.0003717326,0.0000643218,0.00002038192,0.0003325903],"genre_scores_gemma":[0.9941083,0.00000947678,0.004830678,0.0002082219,0.0002248743,0.00002768462,0.0004074938,0.00004194548,0.0001413474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02830854,"threshold_uncertainty_score":0.6645781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003539722103127472,"score_gpt":0.2370160838173749,"score_spread":0.2334763617142474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}