{"id":"W2081235875","doi":"10.1021/jm061343w","title":"Calcitonin Gene-Related Peptide Analogues with Aza and Indolizidinone Amino Acid Residues Reveal Conformational Requirements for Antagonist Activity at the Human Calcitonin Gene-Related Peptide 1 Receptor","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Peptide; Calcitonin; Amino acid; Calcitonin gene-related peptide; Antagonist; Stereochemistry; Peptide sequence; Alanine; Biochemistry; Receptor; Pharmacology; Neuropeptide; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179665,0.0002085911,0.0001903589,0.00008026339,0.00008869357,0.000139438,0.0002016574,0.0001780659,0.000756293],"category_scores_gemma":[0.0001650404,0.0001043738,0.0001605111,0.00009549838,0.0001548327,0.0001313633,0.0000845961,0.000328288,0.0002124506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818656,"about_ca_system_score_gemma":0.0001573858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003557914,"about_ca_topic_score_gemma":0.0006845075,"domain_scores_codex":[0.9998966,0.0000246024,0.00001054273,0.00001623069,0.00002274337,0.0000292639],"domain_scores_gemma":[0.9999187,0.00001979001,0.00002872853,0.000008591051,0.000008539842,0.00001565002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001862521,0.00002674298,0.00009248727,0.00001640318,0.000003312628,0.00005389233,0.00001215832,0.0002401471,0.9984338,0.00006840447,0.000010518,0.0008557861],"study_design_scores_gemma":[0.00007229536,0.001475391,0.001207327,0.000003896973,0.00001720094,0.0002491714,0.00001512881,0.001097031,0.9948828,0.00003306367,0.0009384073,0.000008266273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976688,0.0004735413,0.0007716506,0.00003125416,0.000008333977,0.00002321449,0.00005485244,0.00001471174,0.0009537081],"genre_scores_gemma":[0.9969192,0.0003881743,0.001760038,0.00003243957,0.000005909442,0.00002005576,0.0001116684,0.000005922114,0.0007565709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000756293,"threshold_uncertainty_score":0.002530038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244589868830054,"score_gpt":0.2978906078214574,"score_spread":0.2654447091331568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}