{"id":"W2081244127","doi":"10.1371/journal.pone.0058898","title":"Inhibition of Rac and ROCK Signalling Influence Osteoblast Adhesion, Differentiation and Mineralization on Titanium Topographies","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Osteoblast; Bone sialoprotein; Rho-associated protein kinase; RUNX2; RHOA; Chemistry; Cell biology; Actin cytoskeleton; Mineralization (soil science); Focal adhesion; Osteocalcin; Adhesion; Biology; Signal transduction; Alkaline phosphatase; Cytoskeleton; Biochemistry; Cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000915029,0.0002753368,0.0002693291,0.0001657958,0.0001161614,0.0002435331,0.0002049004,0.0001868789,0.001301096],"category_scores_gemma":[0.0001242764,0.0001530547,0.0002062942,0.0001090416,0.00017727,0.0001098062,0.0001955057,0.0002596477,0.0002824444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035189,"about_ca_system_score_gemma":0.0002230932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435881,"about_ca_topic_score_gemma":0.002647601,"domain_scores_codex":[0.9998143,0.0000187947,0.00001355804,0.00002229145,0.00007131543,0.00005977946],"domain_scores_gemma":[0.9999318,0.0000185309,0.00001834037,0.000005097611,0.00001123839,0.0000149758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007047013,0.000009106307,0.0000535532,0.00002559552,0.000001939249,0.00001700802,0.000005246065,0.0000614856,0.9991471,0.0000263114,0.00001771479,0.0005645839],"study_design_scores_gemma":[0.000007304966,0.0001379515,0.002158281,0.00000292252,0.00001190592,0.00004136573,0.00001680014,0.001077601,0.9956168,0.00001440452,0.0009106372,0.000004026867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943897,0.001056156,0.001796304,0.00004643821,0.0000204805,0.00001676028,0.000167204,0.00005389784,0.002453102],"genre_scores_gemma":[0.99434,0.0007393049,0.001494421,0.0000207488,0.000005288375,0.0000210022,0.0001571442,0.00001333612,0.003208781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435881,"threshold_uncertainty_score":0.004352629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058614619794208,"score_gpt":0.1666931462350738,"score_spread":0.1561070000371318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}