{"id":"W2081282825","doi":"10.1073/pnas.0305862101","title":"Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of British Columbia","funders":"","keywords":"Proteases; Protease; Biology; Biochemistry; Extracellular matrix; Matrix metalloproteinase; Cell biology; Chemistry; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001478767,0.0001362203,0.0001827862,0.0001070364,0.000147296,0.00002486949,0.0007258353,0.0001499681,0.000007303644],"category_scores_gemma":[0.0006763629,0.0001002891,0.0001317188,0.000430947,0.0005578359,0.00006603068,0.0001376915,0.0001220594,0.000001276349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002331174,"about_ca_system_score_gemma":0.0001357477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002520257,"about_ca_topic_score_gemma":3.058364e-7,"domain_scores_codex":[0.9982124,0.00001351208,0.0005312979,0.0003327085,0.0007450471,0.000165039],"domain_scores_gemma":[0.9986821,0.00001023578,0.0007813122,0.00002715137,0.000452161,0.00004699551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006507321,0.0001158116,0.0001055655,0.0001228088,0.00002321397,7.944467e-9,0.00004394949,0.0001566456,0.9831489,0.01617388,0.00002194409,0.00002216092],"study_design_scores_gemma":[0.0003980738,0.0001454692,0.0006746335,0.00007621029,0.00001957495,0.000005197168,0.00007750757,0.00007900146,0.9609085,0.03748903,0.00001965618,0.0001071281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975795,0.0001550982,0.00004529822,0.000752671,0.0000186225,0.0009983716,0.00004461397,0.000007997898,0.0003978438],"genre_scores_gemma":[0.9951999,0.0000312114,0.004425229,0.00005936574,0.00007693196,0.00009656014,0.000002104715,0.000007255024,0.0001014093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02224042,"threshold_uncertainty_score":0.408967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02627266669172125,"score_gpt":0.2847269692163139,"score_spread":0.2584543025245926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}