{"id":"W2081338931","doi":"10.4161/cbt.8.21.9803","title":"Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells","year":2009,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"ADAM10; Triptolide; Chemistry; Cancer research; Cancer cell; Molecular biology; Apoptosis; Disintegrin; Metalloproteinase; Biology; Cancer; Biochemistry; Internal medicine; Matrix metalloproteinase; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009798675,0.000201367,0.0004804888,0.0001541818,0.00002531005,0.000005212083,0.00009104209,0.0001372715,0.0005686656],"category_scores_gemma":[0.000008452941,0.00013779,0.00007748679,0.0002265304,0.0001569489,0.00005751818,0.00001293789,0.0001707094,0.00000162809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788418,"about_ca_system_score_gemma":0.0001441549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006350389,"about_ca_topic_score_gemma":0.0001910471,"domain_scores_codex":[0.9989883,0.00008724947,0.0002575556,0.000345633,0.00008384461,0.000237435],"domain_scores_gemma":[0.9994009,0.00002770479,0.00009487391,0.0002715375,0.0000744707,0.0001305614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002959009,0.0005669778,0.01305254,0.00001811587,0.0001475365,0.0000329742,0.0002603625,0.00000265392,0.7423044,0.000116559,0.0003501736,0.2401886],"study_design_scores_gemma":[0.01320956,0.005235889,0.1907683,0.0002844443,0.0001634723,0.00001529592,0.000110244,0.00005029137,0.7739753,0.00216523,0.01359144,0.0004305881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587959,0.03872896,0.000002377513,0.001630326,0.0001667621,0.0004811606,0.00004844034,0.00002784087,0.0001182307],"genre_scores_gemma":[0.9931828,0.004760956,0.0003342453,0.001000906,0.0001709773,0.000115604,0.00002363885,0.00001349917,0.0003973873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.239758,"threshold_uncertainty_score":0.6226489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03794065110330194,"score_gpt":0.3744694497610418,"score_spread":0.3365287986577399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}