{"id":"W2081341089","doi":"10.1046/j.1365-2036.2002.01341.x","title":"Dose ranging pharmacokinetic trial of high‐dose alicaforsen (intercellular adhesion molecule‐1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease","year":2002,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Crohn's disease; Pharmacokinetics; Gastroenterology; Infliximab; Internal medicine; Cmax; Nausea; Intercellular Adhesion Molecule-1; Surgery; Disease; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004753946,0.0006370057,0.001150313,0.0002680033,0.0002175757,0.0005699883,0.0005462301,0.0009372159,0.001851386],"category_scores_gemma":[0.0007242148,0.0003139886,0.0004165942,0.0003435539,0.0007477874,0.0004866556,0.0001775146,0.001661671,0.000410687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378256,"about_ca_system_score_gemma":0.000627218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004663933,"about_ca_topic_score_gemma":0.0005959802,"domain_scores_codex":[0.9997151,0.0001351522,0.00001353189,0.00005142383,0.00003369808,0.00005091588],"domain_scores_gemma":[0.9994766,0.0001309659,0.0001328272,0.00004713868,0.00002619352,0.0001862526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7447827,0.04484502,0.004565495,0.0003456003,0.0006509371,0.0001816057,0.0002653786,0.00312876,0.1282583,0.0002341912,0.0008499144,0.07189202],"study_design_scores_gemma":[0.2576092,0.7049454,0.01347428,0.00002724127,0.0003872528,0.0003138469,0.00007182351,0.002009459,0.01879105,0.0001192965,0.00221675,0.00003437933],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986889,0.0004256011,0.0001621848,0.00005230846,0.00002124661,0.0001333629,0.00007888691,0.00002940141,0.0004081854],"genre_scores_gemma":[0.9980855,0.0004246912,0.0003565501,0.0001116668,0.0000534395,0.0001671118,0.0002346361,0.000007779618,0.0005585669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851386,"threshold_uncertainty_score":0.006193459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861753327339881,"score_gpt":0.2797373235504585,"score_spread":0.2611197902770597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}