{"id":"W2081346894","doi":"10.1016/j.celrep.2015.03.019","title":"E4F1 Is a Master Regulator of CHK1-Mediated Functions","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Biology; Regulator; Mitosis; CHEK1; Genome instability; DNA damage; Haematopoiesis; Cell cycle; Stem cell; Progenitor cell; Ectopic expression; Cell cycle checkpoint; G2-M DNA damage checkpoint; DNA replication; Cancer research; Apoptosis; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803895,0.0001012264,0.0001198839,0.00003137663,0.00001695327,0.000006664158,0.00005845867,0.0001331314,0.00007730357],"category_scores_gemma":[0.0000843786,0.00009561691,0.00008248122,0.00007023181,0.00003664497,0.000002468135,0.0000813381,0.00004068281,0.00003062119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001087965,"about_ca_system_score_gemma":0.000127952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000098167,"about_ca_topic_score_gemma":0.000002530938,"domain_scores_codex":[0.9991265,0.00001926927,0.0002642743,0.0002826591,0.0001593307,0.000147966],"domain_scores_gemma":[0.9989615,0.000003115242,0.0001806599,0.0005761149,0.000146798,0.0001317939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002121942,0.00006218792,0.001850646,0.00001361344,0.0000214582,0.0000480848,0.00005704146,0.00001039815,0.9579052,0.000003180209,0.0398569,0.0001501035],"study_design_scores_gemma":[0.0001886183,0.0001552491,0.0002725355,0.00000519062,0.00001789761,0.0001012551,0.00006986859,0.00001736464,0.8575765,0.00009868691,0.1413951,0.0001017513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836324,0.0003236896,0.0005336505,0.0000473602,0.0004731073,0.0001350756,0.00000832204,0.00002096254,0.01482536],"genre_scores_gemma":[0.973579,0.000006574589,0.0005487555,0.0001479545,0.0001017031,0.00001255393,0.0001001128,0.00002118419,0.02548208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015382,"threshold_uncertainty_score":0.3899145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574108812856508,"score_gpt":0.2172239182782156,"score_spread":0.2014828301496505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}