{"id":"W2081346894","doi":"10.1016/j.celrep.2015.03.019","title":"E4F1 Is a Master Regulator of CHK1-Mediated Functions","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Biology; Regulator; Mitosis; CHEK1; Genome instability; DNA damage; Haematopoiesis; Cell cycle; Stem cell; Progenitor cell; Ectopic expression; Cell cycle checkpoint; G2-M DNA damage checkpoint; DNA replication; Cancer research; Apoptosis; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545085,0.0007092583,0.0003635795,0.0006969317,0.0004209803,0.0005746112,0.0003787343,0.0003919592,0.001813752],"category_scores_gemma":[0.0002903349,0.0001902547,0.0002297322,0.0003572006,0.0003354718,0.000383685,0.0005471206,0.0003445031,0.0006748919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006524946,"about_ca_system_score_gemma":0.0002796289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008815847,"about_ca_topic_score_gemma":0.0006624881,"domain_scores_codex":[0.9998335,0.0000134477,0.00001039665,0.00005416536,0.00004109777,0.00004742588],"domain_scores_gemma":[0.9998374,0.00002410711,0.0000602797,0.00002005055,0.0000205874,0.00003747645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002173119,0.00002310228,0.003823235,0.0001010184,0.00001695584,0.0002701956,0.00003007684,0.0003298377,0.9828113,0.0006768384,0.0002505358,0.01144954],"study_design_scores_gemma":[0.00001445178,0.00008718831,0.03469849,0.00001096483,0.00001302868,0.001029711,0.00003495232,0.0009700315,0.9517025,0.0002609415,0.01116215,0.00001565235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595491,0.01864285,0.01378316,0.0002468499,0.00007194197,0.00004752413,0.00174782,0.0005596009,0.005351112],"genre_scores_gemma":[0.9881165,0.001898241,0.003051176,0.00003470348,0.00001538807,0.00001776908,0.001417819,0.00004205341,0.005406292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001813752,"threshold_uncertainty_score":0.006067574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574108812856508,"score_gpt":0.2172239182782156,"score_spread":0.2014828301496505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}