{"id":"W2081358841","doi":"10.1158/1538-7445.am10-3168","title":"Abstract 3168: Knock down of m-calpain in a mouse breast carcinoma cell line reduced tumor growth in mouse engraftment studies and compromises the Akt pathway and in vitro cell migration","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Gene knockdown; Small hairpin RNA; Calpastatin; Protein kinase B; Cell biology; Biology; Cell growth; Cell culture; PI3K/AKT/mTOR pathway; Focal adhesion; Cancer research; Molecular biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899105,0.0005527476,0.000341652,0.0004692334,0.0001974469,0.0002976813,0.0003286231,0.0005562561,0.003507406],"category_scores_gemma":[0.00009868543,0.0002076428,0.0004368532,0.0002862222,0.0002435921,0.0002566861,0.0001692148,0.001253149,0.001142064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992719,"about_ca_system_score_gemma":0.0002404275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242513,"about_ca_topic_score_gemma":0.00136285,"domain_scores_codex":[0.9997326,0.0000241451,0.0000401237,0.00005677755,0.00008605378,0.00006027878],"domain_scores_gemma":[0.9998565,0.00001634994,0.0000376992,0.00002250837,0.00001766232,0.00004934123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008089708,0.00005046614,0.00006272125,0.00002183241,0.000003627306,0.00003644298,0.000008225033,0.00002429363,0.9991565,0.0000631681,0.00008397795,0.0004079354],"study_design_scores_gemma":[0.00002813811,0.0002478863,0.001293891,0.000004595726,0.00001317534,0.0001663619,0.0000145254,0.0005728404,0.9954353,0.00002086458,0.00220002,0.000002371663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856477,0.002128547,0.004949733,0.0004033369,0.0002037453,0.00011582,0.002832264,0.0003710303,0.003347779],"genre_scores_gemma":[0.9714428,0.001250471,0.005315112,0.000170662,0.00003137116,0.0001955225,0.003624918,0.00008528143,0.0178838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003507406,"threshold_uncertainty_score":0.01173341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0253374878706195,"score_gpt":0.3048000975003609,"score_spread":0.2794626096297413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}