{"id":"W2081397479","doi":"10.1529/biophysj.106.100545","title":"Skeletal and Cardiac Ryanodine Receptors Exhibit Different Responses to Ca2+ Overload and Luminal Ca2+","year":2007,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Nunavut Wildlife Research Trust; Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"RYR1; Ryanodine receptor 2; Ryanodine receptor; Endoplasmic reticulum; HEK 293 cells; Chemistry; Lizard; Cardiac muscle; Skeletal muscle; Cell biology; Biophysics; Biochemistry; Biology; Receptor; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002044496,0.0001400071,0.0001451984,0.00006634884,0.0001456523,0.00005098083,0.00004668309,0.0001427663,0.00001575791],"category_scores_gemma":[0.00006423918,0.0001131669,0.00008174896,0.00006279664,0.00007754647,0.000006551326,0.00006614852,0.0001699424,0.000006134953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000226612,"about_ca_system_score_gemma":0.00002042259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005716523,"about_ca_topic_score_gemma":0.000002703703,"domain_scores_codex":[0.9991506,0.0000533216,0.0001748438,0.000218828,0.0001836001,0.0002187787],"domain_scores_gemma":[0.9994663,0.00002015214,0.00005590098,0.00009185576,0.00007971564,0.0002860979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005194977,0.00004697971,0.002691294,0.00000550718,0.00003142916,0.000005862398,0.00006110498,0.00000177552,0.9829443,0.0000696256,0.002800762,0.01082184],"study_design_scores_gemma":[0.001202393,0.001751916,0.268102,0.00003669662,0.00005437324,0.0001909745,0.00033637,0.00005857187,0.603821,0.00004667783,0.1239143,0.0004846802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971534,0.0001458953,0.00123815,0.0003936904,0.0008715036,0.0000817735,0.000009720317,0.000007224458,0.00009865413],"genre_scores_gemma":[0.9958016,0.0001247856,0.0001286163,0.0001534092,0.002526281,0.000001949915,0.00001609552,0.00001289203,0.001234318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3791233,"threshold_uncertainty_score":0.4614812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009976322247962756,"score_gpt":0.2519522178021652,"score_spread":0.2419758955542025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}