{"id":"W2081397479","doi":"10.1529/biophysj.106.100545","title":"Skeletal and Cardiac Ryanodine Receptors Exhibit Different Responses to Ca2+ Overload and Luminal Ca2+","year":2007,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Nunavut Wildlife Research Trust; Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"RYR1; Ryanodine receptor 2; Ryanodine receptor; Endoplasmic reticulum; HEK 293 cells; Chemistry; Lizard; Cardiac muscle; Skeletal muscle; Cell biology; Biophysics; Biochemistry; Biology; Receptor; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006760174,0.0004714132,0.001235336,0.0004557721,0.0003462723,0.0008526848,0.0005729871,0.0009746369,0.001951519],"category_scores_gemma":[0.001125717,0.0007270561,0.0007343916,0.0002889286,0.0007669707,0.00126119,0.0006549709,0.001065198,0.0007040372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003737106,"about_ca_system_score_gemma":0.0001809515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005356207,"about_ca_topic_score_gemma":0.0007643892,"domain_scores_codex":[0.9994693,0.00007552624,0.00006735231,0.00009845727,0.0000918409,0.0001974784],"domain_scores_gemma":[0.9991452,0.0001937285,0.0001204251,0.0001696877,0.0001367928,0.0002343084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000656529,0.00001378233,0.0002191956,0.00002120568,0.000009421474,0.00004476395,0.00004906733,0.00001365058,0.9983996,0.00009280297,0.00002469975,0.0004553849],"study_design_scores_gemma":[0.000416382,0.001105834,0.1383722,0.00002225521,0.0002038157,0.002550999,0.0006957697,0.001768843,0.851881,0.0007612517,0.00213733,0.00008439626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955068,0.001228825,0.001656928,0.0002349077,0.00004690919,0.00001667337,0.0002274514,0.00006955843,0.001011907],"genre_scores_gemma":[0.9927988,0.000906014,0.001508122,0.0003311144,0.00007758848,0.00005831544,0.000795655,0.0001015891,0.003422651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001951519,"threshold_uncertainty_score":0.006528497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009976322247962756,"score_gpt":0.2519522178021652,"score_spread":0.2419758955542025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}