{"id":"W2081409454","doi":"10.1126/science.1256337","title":"Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":566,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hôpital Maisonneuve-Rosemont; Occupational Cancer Research Centre; University Health Network; University of Toronto; Université de Montréal; University of British Columbia; Institute for Research in Immunology and Cancer","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Haematopoiesis; Stem cell; Cord blood; Progenitor cell; Ex vivo; Aryl hydrocarbon receptor; Transplantation; Biology; Hematopoietic stem cell transplantation; Hematopoietic stem cell; Genetic enhancement; Cancer research; Cell biology; In vivo; Immunology; Gene; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006931966,0.00024211,0.0001439957,0.000226936,0.0001132918,0.0001299302,0.000142366,0.0001334579,0.001579368],"category_scores_gemma":[0.0001192345,0.00006614209,0.0001075347,0.0001662175,0.0001433846,0.00009402567,0.0001658282,0.0003125806,0.0003535203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001233914,"about_ca_system_score_gemma":0.0001461913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003270968,"about_ca_topic_score_gemma":0.0007415129,"domain_scores_codex":[0.9999462,0.00001181449,0.000004797626,0.000008197324,0.00001417416,0.00001479867],"domain_scores_gemma":[0.9999576,0.00001115639,0.00001382154,0.000003688212,0.000003646435,0.00001004014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004067702,0.0001038139,0.0005760264,0.0002211215,0.000006881967,0.0002076624,0.0000564811,0.0004253605,0.9548706,0.0008461273,0.0002755541,0.04200361],"study_design_scores_gemma":[0.00006635417,0.002034031,0.002753141,0.00001760585,0.00001904058,0.000671951,0.0000339684,0.0003290182,0.9723964,0.0001389415,0.02153054,0.000009039691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660872,0.0193202,0.004688809,0.0002079352,0.00004617264,0.000142679,0.0006480702,0.0001577752,0.008701022],"genre_scores_gemma":[0.9840403,0.008523454,0.003093204,0.00006599272,0.00002251321,0.00008649557,0.0005882249,0.00001137903,0.003568523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001579368,"threshold_uncertainty_score":0.005283535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774206497132337,"score_gpt":0.2750576283109533,"score_spread":0.2573155633396299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}