{"id":"W2081409454","doi":"10.1126/science.1256337","title":"Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":566,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hôpital Maisonneuve-Rosemont; Occupational Cancer Research Centre; University Health Network; University of Toronto; Université de Montréal; University of British Columbia; Institute for Research in Immunology and Cancer","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Haematopoiesis; Stem cell; Cord blood; Progenitor cell; Ex vivo; Aryl hydrocarbon receptor; Transplantation; Biology; Hematopoietic stem cell transplantation; Hematopoietic stem cell; Genetic enhancement; Cancer research; Cell biology; In vivo; Immunology; Gene; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005761029,0.0001282202,0.0002835383,0.0001491347,0.0001663737,0.00002339271,0.0002451994,0.00004876414,0.00003653766],"category_scores_gemma":[0.00002178498,0.0001100953,0.0000541256,0.0004908908,0.0004727791,0.0001109699,0.00003486194,0.00008402921,0.00004674402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004917288,"about_ca_system_score_gemma":0.0001617086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008693263,"about_ca_topic_score_gemma":0.000003128803,"domain_scores_codex":[0.9984044,0.0000415347,0.000303681,0.0003410966,0.0006181645,0.0002910923],"domain_scores_gemma":[0.9990247,0.00007895508,0.0001763995,0.0003909729,0.0001601623,0.0001688015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001538511,0.0002185331,0.03795678,0.001020548,0.000008108478,0.00001038162,0.006154949,0.00000818826,0.9521492,0.002075367,0.00003274511,0.0003497828],"study_design_scores_gemma":[0.0007869662,0.0002130614,0.04129483,0.0002988355,0.00004023418,0.00004557002,0.0009870874,0.000178821,0.9555477,0.0003724802,0.0001041261,0.0001303277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810026,0.00005382796,0.0009566975,0.000118942,0.000109746,0.00022654,0.0000021791,0.00007831459,0.01745118],"genre_scores_gemma":[0.9977043,0.000006485082,0.001793501,0.00008256456,0.00003423323,0.000007815011,0.000002197103,0.00001271907,0.0003562374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01709494,"threshold_uncertainty_score":0.4489558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774206497132337,"score_gpt":0.2750576283109533,"score_spread":0.2573155633396299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}