{"id":"W2081427468","doi":"10.4161/epi.2.2.4613","title":"Induction of DNA Hypomethylation by Tumor Hypoxia","year":2007,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Biology; DNA methylation; Epigenetics; Cancer research; Colorectal cancer; Methylation; Tumor hypoxia; CpG site; Cancer; Hypoxia (environmental); Tumor microenvironment; Cancer cell; Internal medicine; Gene expression; Genetics; DNA; Gene; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005702075,0.0001445942,0.0001389714,0.00008336259,0.00005764394,0.00001056172,0.000131121,0.0001647956,0.00002074868],"category_scores_gemma":[0.0001525831,0.0001549108,0.0000742904,0.0001867232,0.00007794111,0.000003308876,0.00005128962,0.00007524204,0.000007904273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001641052,"about_ca_system_score_gemma":0.00004004649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002160504,"about_ca_topic_score_gemma":0.00002849098,"domain_scores_codex":[0.9988154,0.00004712724,0.000401241,0.0002749625,0.0002167002,0.0002446217],"domain_scores_gemma":[0.999183,0.00002671969,0.0002067117,0.0003265163,0.000163403,0.00009365625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003342763,0.00006256259,0.006966861,0.00001015726,0.00001907245,4.871351e-7,0.00003528163,0.0001060023,0.9734327,0.00003612243,0.0002959781,0.01900136],"study_design_scores_gemma":[0.0002771703,0.0002977737,0.03764034,0.000005762527,0.00001530669,0.000001285492,0.00003502205,0.00002398842,0.9332188,0.0003928817,0.02792961,0.0001621036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550607,0.004100597,0.03851154,0.00003159113,0.0002919808,0.0001581208,0.00001946718,0.00001070738,0.001815279],"genre_scores_gemma":[0.9944659,0.0004994306,0.004167163,0.0000452008,0.0002586448,0.000003854222,0.0001349811,0.00002889941,0.0003958775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04021393,"threshold_uncertainty_score":0.6317078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099472427675639,"score_gpt":0.2578657632867888,"score_spread":0.2468710390100325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}